MAP1LC3B2
Microtubule-associated proteins 1A/1B light chain 3 beta 2
Protein Summary
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
- ENST00000556529
- ENSP00000450524
- ENSG00000258102
- ATG8G
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.72 | ||
cellular component | 0.59 | ||
cell line | 0.53 | ||
transcription factor | 0.53 | ||
histone modification site profile | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.29 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 31 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.29 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 31 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0