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Tbio
MAP1LC3B
Microtubule-associated proteins 1A/1B light chain 3B

Protein Summary
Description
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268607
  • ENSP00000268607
  • ENSG00000140941

Symbol
  • MAP1ALC3
  • LC3B
  • ATG8F
  • MAP1LC3B-a
  • MAP1A/1BLC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
kinase perturbation
1
transcription factor binding site profile
0.98
transcription factor perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1033.48   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 1042   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1033.48   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 1042   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
ATG7
Tchem
Novelty:  0.00120728
Score:  0.997
Data Source:  STRINGDB
FUNDC1
Tbio
Novelty:  0.02333176
Score:  0.996
Data Source:  Reactome,STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
Score:  0.996
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.994
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.993
Data Source:  STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.992
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.992
Data Source:  Reactome,STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.987
Data Source:  Reactome,STRINGDB
OPTN
Tbio
Novelty:  0.00080427
Score:  0.983
Data Source:  STRINGDB
ATG4A
Tbio
Family:  Enzyme
Novelty:  0.04073485
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (68)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Membrane Trafficking
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Membrane Trafficking
Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
2
2
1
6.6
65.7
anxiety measurement
1
1
1
61
self reported educational attainment
1
1
1
55.2
smoking status measurement
2
1
2
51.4
neuroticism measurement
4
3
2
5.8
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
1
6.6
65.7
anxiety measurement
1
61
self reported educational attainment
1
55.2
smoking status measurement
2
51.4
neuroticism measurement
2
5.8
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 beta
746157
Dog
microtubule associated protein 1 light chain 3 beta
479619
Horse
microtubule-associated proteins 1A/1B light chain 3B
100060547
Cow
microtubule associated protein 1 light chain 3 beta
408001
Pig
microtubule associated protein 1 light chain 3 beta
100462754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 beta
Dog
microtubule associated protein 1 light chain 3 beta
Horse
microtubule-associated proteins 1A/1B light chain 3B
Cow
microtubule associated protein 1 light chain 3 beta
Pig
microtubule associated protein 1 light chain 3 beta
Publication Statistics
PubMed Score 1033.48
PubMed score by year
PubTator Score 295.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title