Tbio MAP1LC3A Microtubule-associated proteins 1A/1B light chain 3A

Protein Summary

Description

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9H492
• E1P5P4
• E1P5P5
• Q9BXW5

Gene Name

• MAP1LC3A

Ensembl ID

• ENST00000360668
• ENSP00000353886
• ENSG00000101460
• ENST00000374837
• ENSP00000363970
• ENST00000397709
• ENSP00000380821

Symbol

• LC3
• LC3A
• ATG8E
• MAP1ALC3
• MAP1BLC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
disease perturbation	0.83
small molecule perturbation	0.77
cellular component	0.7
interacting protein	0.69

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Proteins 1a/1b Light Chain 3a

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Proteins 1a/1b Light Chain 3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.44   (req: < 5)

Gene RIFs: 203   (req: <= 3)

Antibodies: 1228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.44   (req: >= 5)

Gene RIFs: 203   (req: > 3)

Antibodies: 1228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0