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Tchem
MAP1B
Microtubule-associated protein 1B

Protein Summary
Description
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296755
  • ENSP00000296755
  • ENSG00000131711

Symbol
  • MAP5
  • FUTSCH
  • PPP1R102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.98
transcription factor perturbation
0.98
small molecule perturbation
0.86
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.47   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.47   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (153)
RASSF1
Tbio
Novelty:  0.00137149
p_int:  0.999743557
p_ni:  0.000256443
p_wrong:  1e-9
Score:  0.493
Data Source:  BioPlex,STRINGDB
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
p_int:  0.998152311
p_ni:  0.001847689
Data Source:  BioPlex
HSPB6
Tbio
Novelty:  0.00317712
p_int:  0.93856264
p_ni:  0.06143736
Score:  0.271
Data Source:  BioPlex,STRINGDB
DBF4B
Tbio
Novelty:  0.48127081
p_int:  0.926424821
p_ni:  0.073575176
p_wrong:  3e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.776521422
p_ni:  0.223478578
Score:  0.411
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.767644256
p_ni:  0.232355744
Score:  0.161
Data Source:  BioPlex,STRINGDB
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.966
Data Source:  STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.957
Data Source:  STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.943
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Lissencephaly gene (LIS1) in neuronal migration and development
PathwayCommons: pid
Reelin signaling pathway
PathwayCommons: pid
Netrin-mediated signaling events
Name
Explore in Pharos
Explore in Source
Lissencephaly gene (LIS1) in neuronal migration and development
Reelin signaling pathway
Netrin-mediated signaling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.2
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.2
6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1B
VGNC:4078
450137
Macaque
microtubule associated protein 1B
574272
Mouse
MGI:1306778
17755
Rat
RGD:3043
29456
Dog
microtubule associated protein 1B
VGNC:42956
478092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1B
Macaque
microtubule associated protein 1B
Mouse
Rat
Dog
microtubule associated protein 1B
Publication Statistics
PubMed Score 457.47
PubMed score by year
PubTator Score 238.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title