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Tclin
MAOA
Amine oxidase [flavin-containing] A

Protein Summary
Description
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338702
  • ENSP00000340684
  • ENSG00000189221
  • ENST00000542639
  • ENSP00000440846

Symbol
  • BRNRS
  • MAO-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
kinase perturbation
0.97
transcription factor perturbation
0.97
gene perturbation
0.91
pathway
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3368.75   (req: < 5)
Gene RIFs: 388   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3368.75   (req: >= 5)
Gene RIFs: 388   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 536
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
phenelzine
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tetracaine
Rendered image for tetracaine
pentamidine
Rendered image for pentamidine
methylthioninium chloride
Rendered image for methylthioninium chloride
nabumetone
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tranylcypromine
Rendered image for tranylcypromine
rasagiline
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isocarboxazid
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moclobemide
Rendered image for moclobemide
pargyline
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Protein-Protein Interactions (133)
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
p_int:  0.999999666
p_ni:  3.2e-7
p_wrong:  1.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
Q9NQG6
Tbio
Novelty:  0.04096049
p_int:  0.99997423
p_ni:  2.6e-8
p_wrong:  0.000025744
Score:  0.485
Data Source:  BioPlex,STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.987
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.968
Data Source:  STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.957
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.951
Data Source:  STRINGDB
AOC2
Tchem
Family:  Enzyme
Novelty:  0.0048282
Score:  0.948
Data Source:  STRINGDB
PNMT
Tchem
Family:  Enzyme
Novelty:  0.00178141
Score:  0.947
Data Source:  STRINGDB
HNMT
Tchem
Family:  Enzyme
Novelty:  0.00100341
Score:  0.946
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (89)
Amine Oxidase reactions (R-HSA-140179)

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Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Reactome
Biological oxidations
Reactome
Cytokine Signaling in Immune system
Reactome
Defective MAOA causes Brunner syndrome (BRUNS)
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Biological oxidations
Cytokine Signaling in Immune system
Defective MAOA causes Brunner syndrome (BRUNS)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase A
VGNC:14699
743285
Mouse
MGI:96915
17161
Rat
RGD:61898
29253
Dog
monoamine oxidase A
VGNC:42953
403450
Horse
monoamine oxidase A
VGNC:19918
100033867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase A
Mouse
Rat
Dog
monoamine oxidase A
Horse
monoamine oxidase A
Publication Statistics
PubMed Score 3368.75
PubMed score by year
PubTator Score 1806.71
PubTator score by year
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Related Publications
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PMID
Year
Title