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Tdark
MANSC1
MANSC domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396349
  • ENSP00000379638
  • ENSG00000111261
  • ENST00000535902
  • ENSP00000438205
  • ENST00000626912
  • ENSP00000487244
  • ENSG00000281818
  • ENST00000629245
  • ENSP00000487587

Symbol
  • LOH12CR3
  • LOH12CR3
  • 9130403P13Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
gene perturbation
0.63
tissue
0.58
cell type or tissue
0.56
tissue sample
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
APOE
Tbio
Novelty:  0.00005049
p_int:  0.999998892
p_ni:  0.000001108
Data Source:  BioPlex
TTYH2
Tbio
Family:  IC
Novelty:  0.19796461
p_int:  0.999996199
p_ni:  4.11e-7
p_wrong:  0.00000339
Score:  0.189
Data Source:  BioPlex,STRINGDB
TP53I11
Tbio
Novelty:  0.21351765
p_int:  0.999995546
p_ni:  0.000004397
p_wrong:  5.7e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
TOM1L1
Tbio
Novelty:  0.09426366
p_int:  0.99998893
p_ni:  0.000011024
p_wrong:  4.7e-8
Data Source:  BioPlex
CLCN7
Tchem
Family:  IC
Novelty:  0.00764796
p_int:  0.9999871
p_ni:  0.0000129
Data Source:  BioPlex
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.999972186
p_ni:  0.000027814
Data Source:  BioPlex
ANKRD13C
Tbio
Novelty:  1.5309683
p_int:  0.999962005
p_ni:  0.000037471
p_wrong:  5.24e-7
Data Source:  BioPlex
TRAM2
Tbio
Novelty:  0.08830467
p_int:  0.999945516
p_ni:  1.7e-8
p_wrong:  0.000054467
Score:  0.189
Data Source:  BioPlex,STRINGDB
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.999849567
p_ni:  0.000150433
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.999785303
p_ni:  0.000214697
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
3
79.3
lymphocyte percentage of leukocytes
2
2
3
79.3
lymphocyte count
2
1
2
73.2
lymphocyte count
2
1
2
73.2
balding measurement
1
2
2
73.1
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
3
79.3
lymphocyte percentage of leukocytes
3
79.3
lymphocyte count
2
73.2
lymphocyte count
2
73.2
balding measurement
2
73.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MANSC domain containing 1
VGNC:13212
738291
Macaque
MANSC domain containing 1
696667
Mouse
MGI:1914979
67729
Rat
RGD:1593458
690606
Dog
MANSC domain containing 1
VGNC:42952
100856733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MANSC domain containing 1
Macaque
MANSC domain containing 1
Mouse
Rat
Dog
MANSC domain containing 1
Publication Statistics
PubMed Score 0.85
PubMed score by year
PubTator Score 0.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title