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Tdark
MANEAL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329006
  • ENSP00000328770
  • ENSG00000185090
  • ENST00000373045
  • ENSP00000362136
  • ENST00000397631
  • ENSP00000380755
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.73
histone modification site profile
0.66
cell line
0.59
tissue sample
0.58
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999627804
p_ni:  0.000372078
p_wrong:  1.18e-7
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.998503162
p_ni:  0.001496834
p_wrong:  4e-9
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.997803557
p_ni:  0.002196373
p_wrong:  7e-8
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.995237757
p_ni:  0.004526256
p_wrong:  0.000235987
Score:  0.185
Data Source:  BioPlex,STRINGDB
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.992965125
p_ni:  0.007034253
p_wrong:  6.22e-7
Data Source:  BioPlex
HS3ST2
Tbio
Family:  Enzyme
Novelty:  0.0611326
p_int:  0.969446899
p_ni:  0.030521847
p_wrong:  0.000031254
Score:  0.183
Data Source:  BioPlex,STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
p_int:  0.96881441
p_ni:  0.03118559
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.957468393
p_ni:  0.041814056
p_wrong:  0.000717551
Data Source:  BioPlex
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.941473165
p_ni:  0.056224299
p_wrong:  0.002302536
Data Source:  BioPlex
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
p_int:  0.906630818
p_ni:  0.091990715
p_wrong:  0.001378467
Score:  0.548
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
1.1
53.7
mathematical ability
3
2
3
53.2
eosinophil percentage of leukocytes
1
1
1
10.7
eosinophil count
2
1
2
9.4
self reported educational attainment
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
53.7
mathematical ability
3
53.2
eosinophil percentage of leukocytes
1
10.7
eosinophil count
2
9.4
self reported educational attainment
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase endo-alpha like
VGNC:9238
745655
Mouse
MGI:2684896
215090
Dog
mannosidase endo-alpha like [Source:HGNC Symbol;Acc:HGNC:26452]
Horse
mannosidase endo-alpha like
VGNC:50716
100069092
Cow
mannosidase endo-alpha like
VGNC:31170
526978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase endo-alpha like
Mouse
Dog
mannosidase endo-alpha like [Source:HGNC Symbol;Acc:HGNC:26452]
Horse
mannosidase endo-alpha like
Cow
mannosidase endo-alpha like
Publication Statistics
PubMed Score 1.06
PubMed score by year
PubTator Score 0.88
PubTator score by year
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Related Publications
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PMID
Year
Title