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Tbio
MAN2A2
Alpha-mannosidase 2x

Protein Summary
Description
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360468
  • ENSP00000353655
  • ENSG00000196547
  • ENST00000559717
  • ENSP00000452948

Symbol
  • MANA2X
  • MANA2X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.9
virus perturbation
0.9
transcription factor binding site profile
0.68
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0