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Tbio
MAN2A1
Alpha-mannosidase 2

Protein Summary
Description
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261483
  • ENSP00000261483
  • ENSG00000112893

Symbol
  • MANA2
  • MANA2
  • MANII
  • GOLIM7
  • AMan II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.91
transcription factor binding site profile
0.89
disease perturbation
0.87
PubMedID
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.29   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.29   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.998137639
p_ni:  0.001862361
Data Source:  BioPlex
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.991498048
p_ni:  0.008501952
Score:  0.548
Data Source:  BioPlex,STRINGDB
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.97108124
p_ni:  0.02891876
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.893279851
p_ni:  0.106720149
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.852100655
p_ni:  0.147899345
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.829986594
p_ni:  0.170013406
Score:  0.529
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.813316092
p_ni:  0.186683908
Data Source:  BioPlex
LYPD2
Tdark
Novelty:  0.55307434
p_int:  0.778139837
p_ni:  0.221860163
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.765854779
p_ni:  0.23414522
Data Source:  BioPlex
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
73.1
mathematical ability
1
2
2
60.4
1
1
1
56
cognitive function measurement
1
1
1
52.7
intelligence
2
2
1
5.5
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
73.1
mathematical ability
2
60.4
1
56
cognitive function measurement
1
52.7
intelligence
1
5.5
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 2A member 1
VGNC:6947
461982
Macaque
mannosidase alpha class 2A member 1
705480
Mouse
MGI:104669
17158
Rat
RGD:3038
25478
Dog
mannosidase alpha class 2A member 1
VGNC:42945
488878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 2A member 1
Macaque
mannosidase alpha class 2A member 1
Mouse
Rat
Dog
mannosidase alpha class 2A member 1
Publication Statistics
PubMed Score 30.29
PubMed score by year
PubTator Score 301.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title