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Tbio
MAMLD1
Mastermind-like domain-containing protein 1

Protein Summary
Description
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262858
  • ENSP00000262858
  • ENSG00000013619
  • ENST00000370401
  • ENSP00000359428
  • ENST00000426613
  • ENSP00000397438
  • ENST00000432680
  • ENSP00000414517

Symbol
  • CG1
  • CXorf6
  • CG1
  • F18
  • HYSP2
  • CXorf6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.74
tissue sample
0.6
transcription factor
0.58
small molecule perturbation
0.52
biological process
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.6   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.6   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
MAML3
Tbio
Novelty:  0.05574812
Score:  0.973
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.966
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.936
Data Source:  STRINGDB
MAML1
Tbio
Novelty:  0.01302751
Score:  0.929
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.917
Data Source:  STRINGDB
TNRC6C
Tbio
Novelty:  0.09764186
Score:  0.916
Data Source:  STRINGDB
HDAC8
Tclin
Family:  Epigenetic
Novelty:  0.0023827
Score:  0.916
Data Source:  STRINGDB
TNRC6B
Tbio
Novelty:  0.04520863
Score:  0.913
Data Source:  STRINGDB
HEYL
Tbio
Family:  TF
Novelty:  0.00643194
Score:  0.912
Data Source:  STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
44
hemoglobin measurement
1
1
1
28.6
refractive error
1
1
1
21.6
serum albumin measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
44
hemoglobin measurement
1
28.6
refractive error
1
21.6
serum albumin measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mastermind like domain containing 1
VGNC:2913
465903
Macaque
mastermind like domain containing 1
703003
Mouse
MGI:3045303
333639
Dog
mastermind like domain containing 1
VGNC:54171
100685170
Pig
mastermind like domain containing 1
100517073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mastermind like domain containing 1
Macaque
mastermind like domain containing 1
Mouse
Dog
mastermind like domain containing 1
Pig
mastermind like domain containing 1
Publication Statistics
PubMed Score 58.60
PubMed score by year
PubTator Score 1231.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title