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Tbio
MAML3
Mastermind-like protein 3

Protein Summary
Description
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000509479
  • ENSP00000421180
  • ENSG00000196782

Symbol
  • KIAA1816
  • GDN
  • MAM2
  • CAGH3
  • ERDA3
  • MAM-2
  • TNRC3
  • mam-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
microRNA
0.79
transcription factor
0.67
cell line
0.56
cell type or tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0