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Tbio
MAML2
Mastermind-like protein 2

Protein Summary
Description
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CX ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000524717
  • ENSP00000434552
  • ENSG00000184384

Symbol
  • KIAA1819
  • MAM2
  • MAM3
  • MAM-3
  • MLL-MAML2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor binding site profile
0.81
cell line
0.74
PubMedID
0.74
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.12   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.12   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.999
Data Source:  Reactome,STRINGDB
MAML1
Tbio
Novelty:  0.01302751
Score:  0.999
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.999
Data Source:  Reactome,STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.999
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.999
Data Source:  Reactome,STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.999
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.942
Data Source:  Reactome,STRINGDB
MAMLD1
Tbio
Novelty:  0.01681081
Score:  0.936
Data Source:  STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.935
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
72.8
hematocrit
2
2
2
68.5
hemoglobin measurement
2
2
2
67.5
1
1
0
1.5
56.2
diastolic blood pressure
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
72.8
hematocrit
2
68.5
hemoglobin measurement
2
67.5
0
1.5
56.2
diastolic blood pressure
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mastermind like transcriptional coactivator 2
700074
Mouse
MGI:2389460
270118
Rat
RGD:1587536
689844
Dog
mastermind like transcriptional coactivator 2
VGNC:42940
485116
Horse
mastermind like transcriptional coactivator 2
VGNC:19904
100067991
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mastermind like transcriptional coactivator 2
Mouse
Rat
Dog
mastermind like transcriptional coactivator 2
Horse
mastermind like transcriptional coactivator 2
Publication Statistics
PubMed Score 141.12
PubMed score by year
PubTator Score 77.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title