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Tchem
MAK
Serine/threonine-protein kinase MAK

Protein Summary
Description
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313243
  • ENSP00000313021
  • ENSG00000111837
  • ENST00000354489
  • ENSP00000346484
  • ENST00000474039
  • ENSP00000476067
  • ENST00000536370
  • ENSP00000442221

Symbol
  • RP62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
histone modification site profile
0.77
protein domain
0.73
cellular component
0.63
microRNA
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (36)
NECTIN3
Tbio
Novelty:  0.01288113
p_int:  0.997773794
p_ni:  2.61e-7
p_wrong:  0.002225944
Score:  0.527
Data Source:  BioPlex,STRINGDB
EVPL
Tbio
Novelty:  0.00274279
Score:  0.75
Data Source:  STRINGDB
RP1L1
Tbio
Novelty:  0.02385711
Score:  0.568
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.548
Data Source:  STRINGDB
KIAA0556
Tdark
Novelty:  0.2186894
Score:  0.547
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.543
Data Source:  STRINGDB
PCARE
Tbio
Novelty:  0.0915146
Score:  0.532
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.531
Data Source:  STRINGDB
BAG2
Tbio
Novelty:  0.00924011
Score:  0.525
Data Source:  STRINGDB
SYCP2L
Tdark
Novelty:  0.19013847
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
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10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
92.6
calcium measurement
2
1
2
46.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
92.6
calcium measurement
2
46.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
male germ cell associated kinase
VGNC:7190
746604
Macaque
male germ cell associated kinase
698353
Mouse
MGI:96913
17152
Rat
RGD:3036
25677
Dog
male germ cell associated kinase
VGNC:42931
478721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
male germ cell associated kinase
Macaque
male germ cell associated kinase
Mouse
Rat
Dog
male germ cell associated kinase
Publication Statistics
PubMed Score 23.30
PubMed score by year
PubTator Score 27.62
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title