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Tbio
MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Protein Summary
Description
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307546
  • ENSP00000304604
  • ENSG00000081026
  • ENST00000369611
  • ENSP00000358624
  • ENST00000369615
  • ENSP00000358628
  • ENST00000369617
  • ENSP00000358630

Symbol
  • KIAA1634
  • MAGI-3
  • dJ730K3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.92
transcription factor binding site profile
0.84
histone modification site profile
0.83
microRNA
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.71   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.71   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
RHBDL1
Tdark
Family:  Enzyme
Novelty:  0.63616927
p_int:  0.999999689
p_ni:  3.11e-7
Score:  0.561
Data Source:  BioPlex,STRINGDB
TCL1B
Tbio
Novelty:  0.00649327
p_int:  0.999999603
p_ni:  3.96e-7
p_wrong:  1e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.999998833
p_ni:  0.000001166
p_wrong:  1e-9
Score:  0.25
Data Source:  BioPlex,STRINGDB
FERMT1
Tbio
Novelty:  0.0088821
p_int:  0.999613379
p_ni:  0.000386621
Score:  0.345
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999179217
p_ni:  0.000814157
p_wrong:  0.000006625
Score:  0.156
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.893
Data Source:  STRINGDB
RAPGEF2
Tbio
Novelty:  0.03353183
Score:  0.853
Data Source:  STRINGDB
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
Score:  0.824
Data Source:  STRINGDB
RAPGEF6
Tbio
Novelty:  0.07979293
Score:  0.819
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
2
1.8
82.9
2
2
1
1.2
64.8
autoimmune thyroid disease
1
1
0
1.2
54.4
1
1
1
44.1
juvenile idiopathic arthritis
1
1
0
1.5
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.8
82.9
1
1.2
64.8
autoimmune thyroid disease
0
1.2
54.4
1
44.1
juvenile idiopathic arthritis
0
1.5
42.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 3
VGNC:8069
457133
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 3
709341
Mouse
MGI:1923484
99470
Rat
RGD:621362
245903
Dog
membrane associated guanylate kinase, WW and PDZ domain containing 3
VGNC:42929
483214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 3
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 3
Mouse
Rat
Dog
membrane associated guanylate kinase, WW and PDZ domain containing 3
Publication Statistics
PubMed Score 25.71
PubMed score by year
PubTator Score 16.81
PubTator score by year
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Related Publications
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PMID
Year
Title