MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Protein Summary
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
- ENST00000307546
- ENSP00000304604
- ENSG00000081026
- ENST00000369611
- ENSP00000358624
- ENST00000369615
- ENSP00000358628
- ENST00000369617
- ENSP00000358630
- KIAA1634
- MAGI-3
- dJ730K3.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.84 | ||
histone modification site profile | 0.83 | ||
microRNA | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.71 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 60 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.71 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 60 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
CAVIN1
Family: Enzyme
Novelty: 0.00780634
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
RHBDL1
Family: Enzyme
Novelty: 0.63616927
p_int: 0.999999689
p_ni: 3.11e-7
Score: 0.561
Data Source: BioPlex,STRINGDB
TCL1B
Novelty: 0.00649327
p_int: 0.999999603
p_ni: 3.96e-7
p_wrong: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
PTPN14
Family: Enzyme
Novelty: 0.01333024
p_int: 0.999998833
p_ni: 0.000001166
p_wrong: 1e-9
Score: 0.25
Data Source: BioPlex,STRINGDB
FERMT1
Novelty: 0.0088821
p_int: 0.999613379
p_ni: 0.000386621
Score: 0.345
Data Source: BioPlex,STRINGDB
LDLRAD4
Novelty: 0.04881486
p_int: 0.999179217
p_ni: 0.000814157
p_wrong: 0.000006625
Score: 0.156
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Rap1 signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Rap1 signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
5 | 2 | 2 | 1.8 | 82.9 | |||||
2 | 2 | 1 | 1.2 | 64.8 | |||||
autoimmune thyroid disease | 1 | 1 | 0 | 1.2 | 54.4 | ||||
1 | 1 | 1 | 44.1 | ||||||
juvenile idiopathic arthritis | 1 | 1 | 0 | 1.5 | 42.1 | ||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.8 | 82.9 | |||||
1 | 1.2 | 64.8 | |||||
autoimmune thyroid disease | 0 | 1.2 | 54.4 | ||||
1 | 44.1 | ||||||
juvenile idiopathic arthritis | 0 | 1.5 | 42.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | membrane associated guanylate kinase, WW and PDZ domain containing 3 | VGNC:8069 | 457133 | |||||
Macaque | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 709341 | ||||||
Mouse | MGI:1923484 | 99470 | ||||||
Rat | RGD:621362 | 245903 | ||||||
Dog | membrane associated guanylate kinase, WW and PDZ domain containing 3 | VGNC:42929 | 483214 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | membrane associated guanylate kinase, WW and PDZ domain containing 3 | |||||
Macaque | membrane associated guanylate kinase, WW and PDZ domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | membrane associated guanylate kinase, WW and PDZ domain containing 3 | |||||
Publication Statistics
PubMed Score 25.71
PubMed score by year
PubTator Score 16.81
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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