MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Protein Summary
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000330909
- ENSP00000331157
- ENSG00000151276
- ENST00000402939
- ENSP00000385450
- ENST00000483466
- ENSP00000420323
- ENST00000497477
- ENSP00000424369
- ENST00000634409
- ENSP00000489444
- ENSG00000282956
- ENST00000634774
- ENSP00000489393
- ENST00000635378
- ENSP00000489391
- ENST00000635471
- ENSP00000489322
- AIP3
- BAIAP1
- BAP1
- TNRC19
- AIP3
- BAP1
- WWP3
- AIP-3
- BAP-1
- BAIAP1
- MAGI-1
- Magi1d
- TNRC19
- MAGI-1b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
viral protein | 1 | ||
virus | 1 | ||
trait | 0.97 | ||
protein domain | 0.92 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.92 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0