Tbio MAGED2 Melanoma-associated antigen D2

Protein Summary

Description

Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q9UNF1
• A6NMX0
• O76058
• Q5BJF3
• Q8NAL6
• Q9H218
• Q9P0U9
• Q9UM52

Gene Name

• MAGED2

Ensembl ID

• ENST00000218439
• ENSP00000218439
• ENSG00000102316
• ENST00000375053
• ENSP00000364193
• ENST00000375058
• ENSP00000364198
• ENST00000375068
• ENSP00000364209
• ENST00000396224
• ENSP00000379526

Symbol

• BCG1
• 11B6
• BCG1
• BCG-1
• HCA10
• BARTS5
• MAGE-D2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
kinase perturbation	0.99
transcription factor perturbation	0.98
interacting protein	0.95
disease perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen D2

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen D2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.34   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 196   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.34   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0