Pharos : Target Details

Tbio

Protein Summary

Description

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]

Uniprot Accession IDs

P43363

Gene Name

MAGEA10

Ensembl ID

ENST00000244096
ENSP00000244096
ENSG00000124260
ENST00000370323
ENSP00000359347

Symbol

MAGE10
CT1.10
MAGE10

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.48

cell line	0.42

protein domain	0.41

transcription factor	0.4

disease	0.38

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.06 (req: < 5)

View Publications

Gene RIFs: 5 (req: <= 3)

View Gene RIFs

Antibodies: 189 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.06 (req: >= 5)

Gene RIFs: 5 (req: > 3)

Antibodies: 189 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (69)

Explore Interacting Targets

1 – 10 of 69

See Interactions on String-DB

NCOA2

Tbio

Novelty: 0.00510052

p_int: 1

Score: 0.422

Data Source: BioPlex,STRINGDB

FOXJ2

Tbio

Family: TF

Novelty: 0.02306032

p_int: 1

Score: 0.406

Data Source: BioPlex,STRINGDB

MAGEA4

Tbio

Novelty: 0.00949096

p_int: 0.999999999

p_wrong: 1e-9

Score: 0.599

Data Source: BioPlex,STRINGDB

FAM216A

Tdark

Novelty: 0.74863593

p_int: 0.999999999

p_ni: 1e-9

Score: 0.422

Data Source: BioPlex,STRINGDB

MAGEA9

Tbio

Novelty: 0.07926412

p_int: 0.999999964

p_ni: 2e-8

p_wrong: 1.6e-8

Data Source: BioPlex

KAT2A

Tchem

Family: Epigenetic

Novelty: 0.00238831

p_int: 0.999999952

p_ni: 4.8e-8

Score: 0.257

Data Source: BioPlex,STRINGDB

KAT2B

Tchem

Family: Epigenetic

Novelty: 0.00172126

p_int: 0.999999937

p_ni: 6.2e-8

p_wrong: 1e-9

Score: 0.495

Data Source: BioPlex,STRINGDB

POU2F1

Tbio

Family: TF

Novelty: 0.00722164

p_int: 0.999999307

p_ni: 6.89e-7

p_wrong: 4e-9

Score: 0.209

Data Source: BioPlex,STRINGDB

NRIP1

Tbio

Novelty: 0.00551568

p_int: 0.999997981

p_ni: 0.000001816

p_wrong: 2.03e-7

Score: 0.209

Data Source: BioPlex,STRINGDB

ERI1

Tbio

Family: Enzyme

Novelty: 0.00959105

p_int: 0.999997942

p_ni: 2e-9

p_wrong: 0.000002056

Score: 0.209

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (2)

Find Similar Targets

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA

nucleoplasm	Inferred from Direct Assay (IDA)	HPA

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID
Chimp	MAGE family member A10	VGNC:12478	107966410

Mouse	melanoma antigen family A, 10	MGI:3588211	236852

Rat	MAGE family member A10	RGD:1563693	293832

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MAGE family member A10

Mouse	melanoma antigen family A, 10

Rat	MAGE family member A10

Publication Statistics

PubMed Score 20.06

PubMed score by year

PubTator Score 30.56

PubTator score by year

Related Publications

Text Mined References (16)

GeneRif Annotations (5)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Nucleus

Polymorphism

Reference proteome

Tumor antigen