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Tbio
MAFK
Transcription factor MafK

Protein Summary
Description
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343242
  • ENSP00000344903
  • ENSG00000198517
  • ENST00000403150
  • ENSP00000386009
  • ENST00000406174
  • ENSP00000385437

Symbol
  • P18
  • NFE2U
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
cell type or tissue
0.75
protein domain
0.73
gene perturbation
0.69
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
NFE2L3
Tbio
Family:  TF
Novelty:  0.03576754
p_int:  0.999993696
p_ni:  1e-8
p_wrong:  0.000006294
Score:  0.842
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.981037606
p_ni:  1.3e-8
p_wrong:  0.018962382
Score:  0.706
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.91832197
p_ni:  6.9e-8
p_wrong:  0.081677961
Data Source:  BioPlex
NFE2
Tchem
Family:  TF
Novelty:  0.00321017
Score:  0.988
Data Source:  Reactome,STRINGDB
NFE2L2
Tchem
Family:  TF
Novelty:  0.00043828
Score:  0.983
Data Source:  STRINGDB
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
Score:  0.91
Data Source:  STRINGDB
HBE1
Tbio
Novelty:  0.00125958
Score:  0.907
Data Source:  STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
Score:  0.907
Data Source:  STRINGDB
HBG1
Tbio
Novelty:  0.00384136
Score:  0.9
Data Source:  STRINGDB
HBB
Tbio
Novelty:  0.00049683
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (129)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
1
1
6.5
smoking behavior
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
6.5
smoking behavior
1
6.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99951
17135
Rat
RGD:628633
246760
Dog
MAF bZIP transcription factor K
VGNC:42922
100856391
Cow
MAF bZIP transcription factor K
VGNC:31142
618914
Pig
MAF bZIP transcription factor K
100521780
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
MAF bZIP transcription factor K
Cow
MAF bZIP transcription factor K
Pig
MAF bZIP transcription factor K
Publication Statistics
PubMed Score 51.85
PubMed score by year
PubTator Score 19.08
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title