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Tbio
MAFG
Transcription factor MafG

Protein Summary
Description
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clust ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357736
  • ENSP00000350369
  • ENSG00000197063
  • ENST00000392366
  • ENSP00000376173

Symbol
  • hMAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
kinase perturbation
0.96
disease perturbation
0.93
transcription factor perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
DEUP1
Tbio
Novelty:  0.13274391
p_int:  0.999998791
p_ni:  0.000001
p_wrong:  2.09e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.999976754
p_ni:  3.62e-7
p_wrong:  0.000022884
Data Source:  BioPlex
NFE2L3
Tbio
Family:  TF
Novelty:  0.03576754
p_int:  0.999938338
p_ni:  1.49e-7
p_wrong:  0.000061513
Score:  0.837
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999830337
p_ni:  1.4e-8
p_wrong:  0.000169649
Score:  0.723
Data Source:  BioPlex,STRINGDB
NFE2
Tchem
Family:  TF
Novelty:  0.00321017
Score:  0.991
Data Source:  Reactome,STRINGDB
NFE2L2
Tchem
Family:  TF
Novelty:  0.00043828
Score:  0.988
Data Source:  STRINGDB
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
Score:  0.957
Data Source:  STRINGDB
FOSB
Tbio
Family:  TF
Novelty:  0.00183071
Score:  0.941
Data Source:  STRINGDB
HBE1
Tbio
Novelty:  0.00125958
Score:  0.91
Data Source:  STRINGDB
MAFK
Tbio
Family:  TF
Novelty:  0.01735942
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
4
5
75.8
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
birth weight
2
2
2
55.2
forced expiratory volume
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
75.8
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
birth weight
2
55.2
forced expiratory volume
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MAF bZIP transcription factor G
715132
Mouse
MGI:96911
17134
Rat
RGD:619953
64188
Dog
MAF bZIP transcription factor G
VGNC:42921
607914
Horse
MAF bZIP transcription factor G
VGNC:19891
100147615
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MAF bZIP transcription factor G
Mouse
Rat
Dog
MAF bZIP transcription factor G
Horse
MAF bZIP transcription factor G
Publication Statistics
PubMed Score 64.66
PubMed score by year
PubTator Score 29.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title