Tbio MAFG Transcription factor MafG

Protein Summary

Description

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

Uniprot Accession IDs

• O15525

Gene Name

• MAFG

Ensembl ID

• ENST00000357736
• ENSP00000350369
• ENSG00000197063
• ENST00000392366
• ENSP00000376173

Symbol

• hMAF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
kinase perturbation	0.96
disease perturbation	0.93
transcription factor perturbation	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Transcription Factor Mafg

Protein / Nucleic Acid Binding / Transcription Factor Mafg

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Transcription Factor Mafg

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (65)

Explore Interacting Targets

1 – 10 of 65

• See Interactions on String-DB

DEUP1

Tbio

Novelty:  0.13274391

p_int:  0.999998791

p_ni:  0.000001

p_wrong:  2.09e-7

Score:  0.237

Data Source:  BioPlex,STRINGDB

ZBTB24

Tbio

Family:  TF

Novelty:  0.041401

p_int:  0.999976754

p_ni:  3.62e-7

p_wrong:  0.000022884

Data Source:  BioPlex

NFE2L3

Tbio

Family:  TF

Novelty:  0.03576754

p_int:  0.999938338

p_ni:  1.49e-7

p_wrong:  0.000061513

Score:  0.837

Data Source:  BioPlex,STRINGDB

BACH1

Tbio

Family:  TF

Novelty:  0.04011328

p_int:  0.999830337

p_ni:  1.4e-8

p_wrong:  0.000169649

Score:  0.723

Data Source:  BioPlex,STRINGDB

NFE2

Tchem

Family:  TF

Novelty:  0.00321017

Score:  0.991

Data Source:  Reactome,STRINGDB

NFE2L2

Tchem

Family:  TF

Novelty:  0.00043828

Score:  0.988

Data Source:  STRINGDB

MAFF

Tbio

Family:  TF

Novelty:  0.01974936

Score:  0.957

Data Source:  STRINGDB

FOSB

Tbio

Family:  TF

Novelty:  0.00183071

Score:  0.941

Data Source:  STRINGDB

HBE1

Tbio

Novelty:  0.00125958

Score:  0.91

Data Source:  STRINGDB

MAFK

Tbio

Family:  TF

Novelty:  0.01735942

Score:  0.907

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (2)

PathwayCommons (1)

WikiPathways (3)

Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (6)

Components (2)

Processes (6)

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1 – 6 of 6

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	2	4	5		75.8
vital capacity	EFO_0004312	1	1	1		73.2
BMI-adjusted waist-hip ratio	EFO_0007788	2	3	3		58.3
birth weight	EFO_0004344	2	2	2		55.2
forced expiratory volume	EFO_0004314	1	1	1		46.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	5		75.8
vital capacity	EFO_0004312	1		73.2
BMI-adjusted waist-hip ratio	EFO_0007788	3		58.3
birth weight	EFO_0004344	2		55.2
forced expiratory volume	EFO_0004314	1		46.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
forced expiratory volume
hair color
parental genotype effect measurement
smoking status measurement
vital capacity
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	MAF bZIP transcription factor G		715132
Mouse	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)	MGI:96911	17134
Rat	MAF bZIP transcription factor G	RGD:619953	64188
Dog	MAF bZIP transcription factor G	VGNC:42921	607914
Horse	MAF bZIP transcription factor G	VGNC:19891	100147615

Species	Name	OMA	EggNOG	Inparanoid
Macaque	MAF bZIP transcription factor G
Mouse	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
Rat	MAF bZIP transcription factor G
Dog	MAF bZIP transcription factor G
Horse	MAF bZIP transcription factor G

Publication Statistics

PubMed Score 64.66

PubMed score by year

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PubTator Score 29.92

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (11)

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PMID	Year	Title