You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAEA
E3 ubiquitin-protein transferase MAEA

Protein Summary
Description
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in eryt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264750
  • ENSP00000264750
  • ENSG00000090316
  • ENST00000303400
  • ENSP00000302830

Symbol
  • EMP
  • EMP
  • EMLP
  • GID9
  • PIG5
  • HLC-10
  • P44EMLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
cellular component
0.77
transcription factor binding site profile
0.7
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
GCG
Tchem
Novelty:  0.00004879
p_int:  0.997263282
p_ni:  0.002736718
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.996334469
p_ni:  0.003665531
Score:  0.986
Data Source:  BioPlex,STRINGDB
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.990469242
p_ni:  0.009530758
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.985704899
p_ni:  0.0142951
p_wrong:  1e-9
Data Source:  BioPlex
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.984040448
p_ni:  0.015959552
Data Source:  BioPlex
INSL6
Tdark
Novelty:  0.06986187
p_int:  0.977016146
p_ni:  0.022983854
Score:  0.169
Data Source:  BioPlex,STRINGDB
DDX50
Tbio
Family:  Enzyme
Novelty:  0.05314506
p_int:  0.970064642
p_ni:  0.029935358
Data Source:  BioPlex
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.969878207
p_ni:  0.030121793
Data Source:  BioPlex
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.967296621
p_ni:  0.032703379
Data Source:  BioPlex
TNNT3
Tbio
Novelty:  0.0212335
p_int:  0.964585914
p_ni:  0.035414086
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
8
3
1.1
97.4
pulse pressure measurement
1
1
1
44.2
heel bone mineral density
2
1
2
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
97.4
pulse pressure measurement
1
44.2
heel bone mineral density
2
24.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
macrophage erythroblast attacher
VGNC:632
461061
Macaque
macrophage erythroblast attacher
702015
Mouse
MGI:1891748
59003
Rat
RGD:1309877
298982
Dog
macrophage erythroblast attacher
VGNC:42918
610745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
macrophage erythroblast attacher
Macaque
macrophage erythroblast attacher
Mouse
Rat
Dog
macrophage erythroblast attacher
Publication Statistics
PubMed Score 123.83
PubMed score by year
PubTator Score 24.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title