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Tbio
MAD2L2
Mitotic spindle assembly checkpoint protein MAD2B

Protein Summary
Description
Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unpro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235310
  • ENSP00000235310
  • ENSG00000116670
  • ENST00000376667
  • ENSP00000365855
  • ENST00000376692
  • ENSP00000365882

Symbol
  • MAD2B
  • REV7
  • REV7
  • FANCV
  • MAD2B
  • POLZ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.71
cellular component
0.68
transcription factor perturbation
0.68
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.48   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.48   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
IFNGR1
Tbio
Novelty:  0.00417244
p_int:  0.999442161
p_ni:  0.000557839
Data Source:  BioPlex
FAM78B
Tdark
Novelty:  0.57441808
p_int:  0.994623007
p_ni:  0.005376993
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.99176304
p_ni:  0.008206465
p_wrong:  0.000030495
Data Source:  BioPlex
ICAM2
Tbio
Novelty:  0.00480584
p_int:  0.9686795
p_ni:  0.0313205
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.966394803
p_ni:  0.024898345
p_wrong:  0.008706852
Data Source:  BioPlex
P10321
Tbio
Novelty:  0.00698601
p_int:  0.961634055
p_ni:  0.038365937
p_wrong:  8e-9
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.956912072
p_ni:  0.04308251
p_wrong:  0.000005418
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.947425595
p_ni:  0.052574405
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.938544409
p_ni:  0.061434738
p_wrong:  0.000020853
Score:  0.155
Data Source:  BioPlex,STRINGDB
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.924577853
p_ni:  0.075422123
p_wrong:  2.4e-8
Data Source:  BioPlex
Pathways (20)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Translesion synthesis by POLI
Reactome
Translesion synthesis by POLK
Reactome
Translesion synthesis by REV1
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Translesion synthesis by POLI
Translesion synthesis by POLK
Translesion synthesis by REV1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
1
1
73.7
midregional pro atrial natriuretic peptide measurement
1
1
1
31.4
basophil percentage of leukocytes
1
1
1
27.3
hip circumference
1
1
1
21.5
triglyceride measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
73.7
midregional pro atrial natriuretic peptide measurement
1
31.4
basophil percentage of leukocytes
1
27.3
hip circumference
1
21.5
triglyceride measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 2 like 2
VGNC:14802
457953
Macaque
mitotic arrest deficient 2 like 2
714527
Mouse
MGI:1919140
71890
Rat
RGD:1307499
313702
Dog
mitotic arrest deficient 2 like 2
VGNC:52216
487443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 2 like 2
Macaque
mitotic arrest deficient 2 like 2
Mouse
Rat
Dog
mitotic arrest deficient 2 like 2
Publication Statistics
PubMed Score 103.48
PubMed score by year
PubTator Score 50.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title