You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAD2L1BP
MAD2L1-binding protein

Protein Summary
Description
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372171
  • ENSP00000361244
  • ENSG00000124688
  • ENST00000451025
  • ENSP00000410818

Symbol
  • CMT2
  • KIAA0110
  • CMT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.79
transcription factor
0.68
transcription factor perturbation
0.68
histone modification site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999992397
p_ni:  0.00000474
p_wrong:  0.000002863
Score:  0.181
Data Source:  BioPlex,STRINGDB
CDC20
Tbio
Novelty:  0.00197887
p_int:  0.999966978
p_ni:  0.000032911
p_wrong:  1.11e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
PYM1
Tbio
Novelty:  0.04117785
p_int:  0.999956955
p_ni:  0.000043039
p_wrong:  6e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.999825188
p_ni:  0.000161274
p_wrong:  0.000013538
Score:  0.228
Data Source:  BioPlex,STRINGDB
LBR
Tbio
Family:  Epigenetic
Novelty:  0.00205961
p_int:  0.999781285
p_ni:  0.000122666
p_wrong:  0.00009605
Score:  0.239
Data Source:  BioPlex,STRINGDB
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.99865544
p_ni:  0.001314273
p_wrong:  0.000030286
Data Source:  BioPlex
RIT1
Tbio
Family:  Enzyme
Novelty:  0.02780594
p_int:  0.998435766
p_ni:  0.001560574
p_wrong:  0.00000366
Score:  0.199
Data Source:  BioPlex,STRINGDB
TOR1AIP1
Tbio
Novelty:  0.09110893
p_int:  0.991658253
p_ni:  0.005853373
p_wrong:  0.002488374
Score:  0.511
Data Source:  BioPlex,STRINGDB
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
p_int:  0.98603074
p_ni:  0.013967862
p_wrong:  0.000001397
Data Source:  BioPlex
NTF3
Tbio
Novelty:  0.00089023
p_int:  0.983134945
p_ni:  0.000349583
p_wrong:  0.016515472
Score:  0.519
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
E2F transcription factor network
PathwayCommons: pid
PLK1 signaling events
Name
Explore in Pharos
Explore in Source
E2F transcription factor network
PLK1 signaling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
52
body height
1
1
1
30.2
refractive error measurement
1
1
1
17.8
vascular endothelial growth factor measurement
1
1
1
15.7
leukocyte count
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
52
body height
1
30.2
refractive error measurement
1
17.8
vascular endothelial growth factor measurement
1
15.7
leukocyte count
1
12.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAD2L1 binding protein
VGNC:3373
462721
Macaque
MAD2L1 binding protein
701099
Mouse
MGI:1913841
66591
Rat
RGD:1309175
316237
Dog
MAD2L1 binding protein
VGNC:42915
474916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAD2L1 binding protein
Macaque
MAD2L1 binding protein
Mouse
Rat
Dog
MAD2L1 binding protein
Publication Statistics
PubMed Score 1.09
PubMed score by year
PubTator Score 125.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title