You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MACROD1
O-acetyl-ADP-ribose deacetylase MACROD1

Protein Summary
Description
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255681
  • ENSP00000255681
  • ENSG00000133315

Symbol
  • LRP16
  • LRP16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
histone modification site profile
0.91
phenotype
0.9
transcription factor binding site profile
0.84
interacting protein
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (52)
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999873663
p_ni:  0.0001262
p_wrong:  1.37e-7
Score:  0.68
Data Source:  BioPlex,STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
p_int:  0.999796769
p_ni:  0.000203231
Score:  0.853
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.999709369
p_ni:  0.000290631
Score:  0.752
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.999636243
p_ni:  0.000363757
Score:  0.583
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999572813
p_ni:  0.000427187
Score:  0.732
Data Source:  BioPlex,STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.99923279
p_ni:  0.000308986
p_wrong:  0.000458223
Data Source:  BioPlex
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.997337581
p_ni:  0.002662419
Score:  0.631
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.964986871
p_ni:  0.035013129
Data Source:  BioPlex
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.95550532
p_ni:  0.000642002
p_wrong:  0.043852678
Data Source:  BioPlex
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.911953403
p_ni:  0.088046597
Score:  0.596
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
15
21
98
waist-hip ratio
3
13
14
98
uric acid measurement
1
3
3
97.7
triglyceride measurement
5
5
7
96.8
urate measurement
3
10
11
96
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
21
98
waist-hip ratio
14
98
uric acid measurement
3
97.7
triglyceride measurement
7
96.8
urate measurement
11
96
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MACRO domain containing 1
VGNC:11908
451285
Mouse
MGI:2147583
107227
Rat
RGD:628701
246233
Dog
MACRO domain containing 1
VGNC:51880
612142
Cow
MACRO domain containing 1
613568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MACRO domain containing 1
Mouse
Rat
Dog
MACRO domain containing 1
Cow
MACRO domain containing 1
Publication Statistics
PubMed Score 35.35
PubMed score by year
PubTator Score 22.84
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title