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Tbio
MACC1
Metastasis-associated in colon cancer protein 1

Protein Summary
Description
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332878
  • ENSP00000328410
  • ENSG00000183742
  • ENST00000400331
  • ENSP00000383185
  • ENST00000589011
  • ENSP00000466864

Symbol
  • 7A5
  • SH3BP4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
virus perturbation
0.88
microRNA
0.67
biological term
0.56
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.73   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.73   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.999575643
p_ni:  0.000424357
Score:  0.527
Data Source:  BioPlex,STRINGDB
MIB2
Tbio
Family:  Enzyme
Novelty:  0.044378
p_int:  0.997375824
p_ni:  0.001347714
p_wrong:  0.001276462
Data Source:  BioPlex
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.996511522
p_ni:  0.003488464
p_wrong:  1.4e-8
Data Source:  BioPlex
FCHO2
Tbio
Novelty:  0.12302279
p_int:  0.991718902
p_ni:  0.008280304
p_wrong:  7.94e-7
Data Source:  BioPlex
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
p_int:  0.974106293
p_ni:  0.025893687
p_wrong:  2e-8
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.940434501
p_ni:  0.059565499
Data Source:  BioPlex
TMEM196
Tdark
Novelty:  0.37594264
Score:  0.738
Data Source:  STRINGDB
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.718
Data Source:  STRINGDB
DTHD1
Tdark
Novelty:  0.53715991
Score:  0.681
Data Source:  STRINGDB
SP4
Tbio
Family:  TF
Novelty:  0.02444442
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
63.9
BMI-adjusted waist circumference
2
3
3
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
63.9
BMI-adjusted waist circumference
3
45.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MACC1, MET transcriptional regulator
VGNC:14044
472302
Macaque
MACC1, MET transcriptional regulator
707470
Mouse
MGI:2685113
238455
Rat
RGD:1309838
314539
Dog
MACC1, MET transcriptional regulator
VGNC:42913
482343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MACC1, MET transcriptional regulator
Macaque
MACC1, MET transcriptional regulator
Mouse
Rat
Dog
MACC1, MET transcriptional regulator
Publication Statistics
PubMed Score 170.73
PubMed score by year
PubTator Score 111.42
PubTator score by year
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Related Publications
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PMID
Year
Title