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Tbio
MAB21L1
Putative nucleotidyltransferase MAB21L1

Protein Summary
Description
Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo (PubMed:27271801). Binds single-stranded RNA (ssRNA) (PubMed:27271801). This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379919
  • ENSP00000369251
  • ENSG00000180660

Symbol
  • CAGR1
  • CAGR1
  • Nbla00126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.67
PubMedID
0.58
tissue sample
0.57
disease perturbation
0.56
microRNA
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.84   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.84   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.999999999
p_ni:  1e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
p_int:  0.999999993
p_ni:  7e-9
Score:  0.896
Data Source:  BioPlex,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.999999631
p_ni:  3.69e-7
Score:  0.846
Data Source:  BioPlex,STRINGDB
PBX3
Tbio
Family:  TF
Novelty:  0.01516183
p_int:  0.999999617
p_ni:  3.82e-7
p_wrong:  1e-9
Score:  0.835
Data Source:  BioPlex,STRINGDB
FAM222A
Tdark
Novelty:  0.41466126
p_int:  0.999987328
p_ni:  0.000012665
p_wrong:  7e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.999973472
p_ni:  0.000026528
Score:  0.183
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
p_int:  0.999896542
p_ni:  0.000103458
Score:  0.85
Data Source:  BioPlex,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  0.998423703
p_ni:  0.000250831
p_wrong:  0.001325466
Score:  0.851
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.848463389
p_ni:  0.15153661
p_wrong:  1e-9
Data Source:  BioPlex
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.791283094
p_ni:  0.18582887
p_wrong:  0.022888036
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
57.6
self reported educational attainment
1
1
1
45.7
1
1
1
31.4
disease progression measurement
1
1
1
31.4
cognitive function measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
57.6
self reported educational attainment
1
45.7
1
31.4
disease progression measurement
1
31.4
cognitive function measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mab-21 like 1
VGNC:13178
467258
Macaque
mab-21 like 1
714439
Mouse
MGI:1333773
17116
Rat
RGD:1589984
688394
Dog
mab-21 like 1
VGNC:42910
486012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mab-21 like 1
Macaque
mab-21 like 1
Mouse
Rat
Dog
mab-21 like 1
Publication Statistics
PubMed Score 13.84
PubMed score by year
PubTator Score 8.54
PubTator score by year
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Related Publications
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PMID
Year
Title