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Tbio
LZTS1
Leucine zipper putative tumor suppressor 1

Protein Summary
Description
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265801
  • ENSP00000265801
  • ENSG00000061337
  • ENST00000381569
  • ENSP00000370981
  • ENST00000522290
  • ENSP00000429263
  • ENST00000616228
  • ENSP00000479534

Symbol
  • FEZ1
  • F37
  • FEZ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
biological process
0.67
cellular component
0.67
microRNA
0.6
disease
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.52   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.52   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.99999991
p_ni:  8.1e-8
p_wrong:  9e-9
Score:  0.818
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999999851
p_ni:  1.49e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
FAM214B
Tdark
Novelty:  1.51760608
Score:  0.818
Data Source:  STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
Score:  0.818
Data Source:  STRINGDB
ALMS1
Tbio
Novelty:  0.00694228
Score:  0.818
Data Source:  STRINGDB
EIF4ENIF1
Tbio
Novelty:  0.03835664
Score:  0.818
Data Source:  STRINGDB
SASH1
Tbio
Novelty:  0.02224739
Score:  0.808
Data Source:  STRINGDB
SIPA1L1
Tdark
Novelty:  0.13134052
Score:  0.804
Data Source:  STRINGDB
FEZ2
Tbio
Novelty:  0.1716508
Score:  0.752
Data Source:  STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
3
3
61.6
triglyceride measurement
1
2
2
42
apolipoprotein A 1 measurement
1
1
1
20.5
body mass index
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
61.6
triglyceride measurement
2
42
apolipoprotein A 1 measurement
1
20.5
body mass index
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine zipper tumor suppressor 1
VGNC:14571
464034
Macaque
leucine zipper tumor suppressor 1
705724
Mouse
MGI:2684762
211134
Rat
RGD:708565
266711
Dog
leucine zipper tumor suppressor 1
VGNC:42905
486136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine zipper tumor suppressor 1
Macaque
leucine zipper tumor suppressor 1
Mouse
Rat
Dog
leucine zipper tumor suppressor 1
Publication Statistics
PubMed Score 65.52
PubMed score by year
PubTator Score 36.50
PubTator score by year
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Related Publications
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PMID
Year
Title