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Tbio
LZTR1
Leucine-zipper-like transcriptional regulator 1

Protein Summary
Description
Probable transcriptional regulator that may play a crucial role in embryogenesis. This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215739
  • ENSP00000215739
  • ENSG00000099949
  • ENST00000646124
  • ENSP00000496779

Symbol
  • TCFL2
  • NS2
  • NS10
  • BTBD29
  • LZTR-1
  • SWNTS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.81
transcription factor perturbation
0.8
small molecule perturbation
0.75
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
MYH6
Tbio
Novelty:  0.00058671
p_int:  0.999999976
p_ni:  3e-9
p_wrong:  2.1e-8
Data Source:  BioPlex
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999999904
p_ni:  9.1e-8
p_wrong:  6e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.999999869
p_ni:  1.31e-7
Data Source:  BioPlex
MYH13
Tbio
Novelty:  0.01077846
p_int:  0.999999499
p_ni:  1.9e-8
p_wrong:  4.81e-7
Data Source:  BioPlex
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999998116
p_ni:  0.000001884
Data Source:  BioPlex
RIT1
Tbio
Family:  Enzyme
Novelty:  0.02780594
p_int:  0.99999777
p_ni:  0.000002147
p_wrong:  8.3e-8
Score:  0.806
Data Source:  BioPlex,STRINGDB
MYH1
Tbio
Novelty:  0.00472973
p_int:  0.999996979
p_ni:  0.000003021
Data Source:  BioPlex
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.999994977
p_ni:  0.000005023
Data Source:  BioPlex
PRPSAP2
Tbio
Family:  Enzyme
Novelty:  0.12017454
p_int:  0.999994334
p_ni:  0.000005666
Score:  0.167
Data Source:  BioPlex,STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.999990931
p_ni:  0.000009054
p_wrong:  1.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
74.7
1
1
1
30.2
1
1
0
1.1
21.5
gut microbiome measurement
1
1
2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
74.7
1
30.2
0
1.1
21.5
gut microbiome measurement
2
15.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine zipper like transcription regulator 1
VGNC:12895
107970370
Mouse
MGI:1914113
66863
Rat
RGD:1309100
360745
Dog
leucine zipper like transcription regulator 1
VGNC:42904
608108
Horse
leucine zipper like transcription regulator 1
VGNC:19872
100050778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine zipper like transcription regulator 1
Mouse
Rat
Dog
leucine zipper like transcription regulator 1
Horse
leucine zipper like transcription regulator 1
Publication Statistics
PubMed Score 50.16
PubMed score by year
PubTator Score 28.32
PubTator score by year
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Related Publications
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PMID
Year
Title