Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

LZIC

Ensembl ID

ENST00000377213
ENSP00000366418
ENSG00000162441
ENST00000377223
ENSP00000366430
ENST00000400903
ENSP00000383695

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91

transcription factor binding site profile	0.83

virus perturbation	0.79

histone modification site profile	0.77

tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 282 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 282 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

See Interactions on String-DB

GINS2

Tbio

Novelty: 0.0078966

p_int: 0.999904491

p_ni: 0.000095509

p_wrong: 1e-9

Score: 0.228

Data Source: BioPlex,STRINGDB

CCNC

Tbio

Novelty: 0.00585842

p_int: 0.999886994

p_ni: 0.000112887

p_wrong: 1.2e-7

Score: 0.663

Data Source: BioPlex,STRINGDB

CDK8

Tchem

Family: Kinase

Novelty: 0.00508026

p_int: 0.998654842

p_ni: 0.001345158

Score: 0.663

Data Source: BioPlex,STRINGDB

CDK19

Tchem

Family: Kinase

Novelty: 0.03132669

p_int: 0.996931526

p_ni: 0.003068473

p_wrong: 1e-9

Score: 0.666

Data Source: BioPlex,STRINGDB

GINS4

Tbio

Novelty: 0.0316194

p_int: 0.995392551

p_ni: 0.004607449

Score: 0.189

Data Source: BioPlex,STRINGDB

FSD1

Tbio

Novelty: 0.03452477

p_int: 0.983701137

p_ni: 0.007434376

p_wrong: 0.008864487

Data Source: BioPlex

MBD5

Tbio

Family: Epigenetic

Novelty: 0.03015349

p_int: 0.982775562

p_ni: 0.005903265

p_wrong: 0.011321172

Score: 0.189

Data Source: BioPlex,STRINGDB

FGB

Tbio

Novelty: 0.00437751

p_int: 0.979735948

p_ni: 0.007151704

p_wrong: 0.013112349

Data Source: BioPlex

CLSTN1

Tbio

Novelty: 0.04056624

Score: 0.63

Data Source: STRINGDB

GPR157

Tdark

Family: GPCR

Novelty: 0.96671087

Score: 0.63

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (1)

Processes (1)

Find Similar Targets

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Macaque	leucine zipper and CTNNBIP1 domain containing		712335

Mouse	leucine zipper and CTNNBIP1 domain containing	MGI:1916401	69151

Rat	leucine zipper and CTNNBIP1 domain containing	RGD:1309253	366507

Dog	leucine zipper and CTNNBIP1 domain containing	VGNC:42903	100855658

Horse	leucine zipper and CTNNBIP1 domain containing	VGNC:19870	100051553

Species	Name	OMA	EggNOG	Inparanoid
Macaque	leucine zipper and CTNNBIP1 domain containing

Mouse	leucine zipper and CTNNBIP1 domain containing

Rat	leucine zipper and CTNNBIP1 domain containing

Dog	leucine zipper and CTNNBIP1 domain containing

Horse	leucine zipper and CTNNBIP1 domain containing

Publication Statistics

PubMed Score 3.57

PubMed score by year

PubTator Score 2.27

PubTator score by year

Related Publications

Text Mined References (10)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Alternative splicing

Coiled coil

Complete proteome

Polymorphism

Reference proteome