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Tbio
LYZL6
Lysozyme-like protein 6

Protein Summary
Description
May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716). This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612374
  • ENSP00000483358
  • ENSG00000277042
  • ENST00000615905
  • ENSP00000483897
  • ENSG00000275722
  • ENST00000618542
  • ENSP00000482955
  • ENST00000632590
  • ENSP00000488304

Symbol
  • LYC1
  • LYC1
  • LYZB
  • UNQ754
  • PRO1485
  • TKAL754
  • HEL-S-6a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.61
cell line
0.51
transcription factor
0.5
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
ANKRD27
Tbio
Novelty:  0.02843267
Score:  0.721
Data Source:  STRINGDB
SPRYD4
Tdark
Novelty:  0.44404169
Score:  0.652
Data Source:  STRINGDB
NAGS
Tbio
Family:  Enzyme
Novelty:  0.0051524
Score:  0.644
Data Source:  STRINGDB
EGFLAM
Tbio
Novelty:  0.02955802
Score:  0.631
Data Source:  STRINGDB
RBMS1
Tbio
Novelty:  0.00520684
Score:  0.612
Data Source:  STRINGDB
TEX38
Tdark
Novelty:  0.45214825
Score:  0.575
Data Source:  STRINGDB
ASTL
Tbio
Family:  Enzyme
Novelty:  0.02265035
Score:  0.56
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.557
Data Source:  STRINGDB
FAM166A
Tdark
Novelty:  32.79136691
Score:  0.552
Data Source:  STRINGDB
CLEC3A
Tdark
Novelty:  0.21498836
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal genotype effect measurement
1
2
2
95
protein measurement
1
2
2
95
fetal genotype effect measurement
1
2
2
95
protein measurement
1
2
2
95
CCL23 measurement
1
1
1
63.1
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal genotype effect measurement
2
95
protein measurement
2
95
fetal genotype effect measurement
2
95
protein measurement
2
95
CCL23 measurement
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lysozyme like 6
716662
Mouse
MGI:1916694
69444
Rat
RGD:1306968
287751
Horse
lysozyme like 6
VGNC:19869
100063794
Cow
lysozyme like 6
VGNC:31118
540048
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lysozyme like 6
Mouse
Rat
Horse
lysozyme like 6
Cow
lysozyme like 6
Publication Statistics
PubMed Score 12.45
PubMed score by year
PubTator Score 5.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title