Protein Summary
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
- ENST00000261267
- ENSP00000261267
- ENSG00000090382
- LZM
- LZM
- LYZF1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
protein complex | 1 | ||
small molecule perturbation | 0.83 | ||
protein domain | 0.73 | ||
drug | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 622.79 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 829 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 622.79 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 829 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (236)
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999137413
p_ni: 0.000862587
Data Source: BioPlex
HBM
Novelty: 0.02658671
p_int: 0.882833683
p_ni: 0.117166297
p_wrong: 2e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
SNX27
Novelty: 0.02419724
p_int: 0.873446276
p_ni: 0.126553722
p_wrong: 2e-9
Data Source: BioPlex
WWOX
Family: Enzyme
Novelty: 0.00335243
p_int: 0.830230513
p_ni: 0.169769422
p_wrong: 6.5e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
HSF2
Family: TF
Novelty: 0.06458223
p_int: 0.779058148
p_ni: 0.22094185
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (9)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 2 | 1 | 2 | 88 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 87.7 | |||||
Oral ulcer | 1 | 1 | 0 | 1.1 | 80.6 | ||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 80.4 | |||||
BMI-adjusted hip circumference | 3 | 3 | 7 | 79.3 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 2 | 88 | |||||
monocyte percentage of leukocytes | 2 | 87.7 | |||||
Oral ulcer | 0 | 1.1 | 80.6 | ||||
granulocyte percentage of myeloid white cells | 1 | 80.4 | |||||
BMI-adjusted hip circumference | 7 | 79.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lysozyme | VGNC:5465 | 450190 | |||||
Macaque | lysozyme | 718361 | ||||||
Mouse | MGI:96897 | 17105 | ||||||
Rat | RGD:3026 | 25211 | ||||||
Dog | lysozyme | VGNC:42901 | 474442 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lysozyme | |||||
Macaque | lysozyme | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysozyme | |||||
Publication Statistics
PubMed Score 622.79
PubMed score by year
PubTator Score 3563.09
PubTator score by year
Related Publications
Text Mined References (99)
GeneRif Annotations (56)
Items per page:
0 of 0
PMID | Year | Title |
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