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Tbio
LYRM4
LYR motif-containing protein 4

Protein Summary
Description
Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330636
  • ENSP00000418787
  • ENSG00000214113

Symbol
  • C6orf149
  • ISD11
  • ISD11
  • CGI-203
  • COXPD19
  • C6orf149
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
trait
0.86
transcription factor binding site profile
0.7
cell type or tissue
0.62
microRNA
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.999999562
p_ni:  3.79e-7
p_wrong:  5.9e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.999966412
p_ni:  0.000004869
p_wrong:  0.000028719
Score:  0.895
Data Source:  BioPlex,STRINGDB
HLA-DPB1
Tbio
Novelty:  0.00185371
p_int:  0.999819057
p_ni:  0.000033578
p_wrong:  0.000147365
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999818204
p_ni:  0.000031862
p_wrong:  0.000149935
Score:  0.167
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.999478237
p_ni:  0.000016708
p_wrong:  0.000505055
Score:  0.167
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.997919704
p_ni:  0.000093716
p_wrong:  0.001986581
Data Source:  BioPlex
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.997
Data Source:  Reactome,STRINGDB
FXN
Tbio
Novelty:  0.00084064
Score:  0.997
Data Source:  Reactome,STRINGDB
FDX2
Tdark
Novelty:  0.05747769
Score:  0.985
Data Source:  STRINGDB
FDX1
Tbio
Novelty:  0.00124491
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
3
79.7
1
1
0
1.1
29
keratinocyte carcinoma
1
1
0
1.1
13.5
1
1
0
1.1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
79.7
0
1.1
29
keratinocyte carcinoma
0
1.1
13.5
0
1.1
13.1
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2683538
380840
Rat
RGD:7672286
102550385
Horse
LYR motif containing 4
VGNC:19861
100050671
Cow
LYR motif containing 4
VGNC:31110
614011
Anole lizard
LYR motif containing 4
100562507
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
LYR motif containing 4
Cow
LYR motif containing 4
Anole lizard
LYR motif containing 4
Publication Statistics
PubMed Score 28.64
PubMed score by year
PubTator Score 15.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title