Tchem LYPLA2 Acyl-protein thioesterase 2

Protein Summary

Description

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity). Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95372
• Q7Z4Z2
• APT-2

Gene Name

• LYPLA2

Ensembl ID

• ENST00000374514
• ENSP00000363638
• ENSG00000011009

Symbol

• APT2
• APT2
• APT-2
• DJ886K2.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.76
metabolite	0.75
histone modification site profile	0.72
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

Palmostatin B

LYPLA2Tchem Enzyme

pKi : 7.47

Palmostatin M

LYPLA2Tchem Enzyme

pIC50 : 8.6

CHEMBL1903566

LYPLA2Tchem Enzyme

pIC50 : 7.77

CHEMBL3133032

LYPLA2Tchem Enzyme

pKi : 6.14

CHEMBL1509398

LYPLA2Tchem Enzyme

pKi : 6.64

CHEMBL3133033

LYPLA2Tchem Enzyme

pIC50 : 6.7

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

KIF3A

Tbio

Novelty:  0.00555124

p_int:  0.999967572

p_ni:  0.000032428

p_wrong:  1e-9

Score:  0.197

Data Source:  BioPlex,STRINGDB

OAZ3

Tbio

Family:  Enzyme

Novelty:  0.02374168

p_int:  0.999963741

p_ni:  0.000036259

Score:  0.161

Data Source:  BioPlex,STRINGDB

SGO2

Tbio

Novelty:  0.05544423

p_int:  0.999811438

p_ni:  0.000188538

p_wrong:  2.4e-8

Score:  0.186

Data Source:  BioPlex,STRINGDB

NYX

Tbio

Novelty:  0.0100148

p_int:  0.999727856

p_ni:  0.000272078

p_wrong:  6.6e-8

Score:  0.217

Data Source:  BioPlex,STRINGDB

MLST8

Tbio

Novelty:  0.00423122

p_int:  0.999640596

p_ni:  0.000273974

p_wrong:  0.00008543

Score:  0.22

Data Source:  BioPlex,STRINGDB

GAP43

Tbio

Novelty:  0.00091023

Score:  0.927

Data Source:  Reactome,STRINGDB

GPCPD1

Tdark

Family:  Enzyme

Novelty:  0.03548168

Score:  0.921

Data Source:  STRINGDB

PLA2G16

Tchem

Novelty:  0.02310886

Score:  0.912

Data Source:  STRINGDB

PLB1

Tbio

Family:  Enzyme

Novelty:  0.01628403

Score:  0.841

Data Source:  STRINGDB

PNPLA6

Tbio

Family:  Enzyme

Novelty:  0.00295195

Score:  0.84

Data Source:  STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

ACHE

Tclin

Family:  Enzyme

KEGG Distance:  2

Common Pathways:  1

1: Glycerophospholipid metabolism

Pathways (4)

Reactome (3)

KEGG (1)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	L1CAM interactions	100 targets	R-HSA-373760

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
L1CAM interactions	100 targets	R-HSA-373760

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (4)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
palmitoyl-(protein) hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
carboxylic ester hydrolase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6	4	6		92.4
eosinophil count	EFO_0004842	3	3	3		91.9
reticulocyte measurement	EFO_0010700	3	2	3		90.5
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		85.5
eosinophil percentage of granulocytes	EFO_0007996	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6		92.4
eosinophil count	EFO_0004842	3		91.9
reticulocyte measurement	EFO_0010700	3		90.5
eosinophil percentage of leukocytes	EFO_0007991	2		85.5
eosinophil percentage of granulocytes	EFO_0007996	1		35

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
Fatty acid metabolism
Hydrolase
Lipid metabolism
Lipoprotein
Palmitate
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
reticulocyte count
reticulocyte measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	lysophospholipase II		719074
Mouse	lysophospholipase 2	MGI:1347000	26394
Rat	lysophospholipase II	RGD:620210	83510
Dog	lysophospholipase II	VGNC:42891	100855579
Horse	lysophospholipase II	VGNC:19857	100071559

Species	Name	OMA	EggNOG	Inparanoid
Macaque	lysophospholipase II
Mouse	lysophospholipase 2
Rat	lysophospholipase II
Dog	lysophospholipase II
Horse	lysophospholipase II

Publication Statistics

PubMed Score 18.33

PubMed score by year

Reset Zoom

PubTator Score 24.84

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (13)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title