Tchem LYPLA1 Acyl-protein thioesterase 1

Protein Summary

Description

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75608
• O43202
• Q9UQF9
• APT-1

Gene Name

• LYPLA1

Ensembl ID

• ENST00000316963
• ENSP00000320043
• ENSG00000120992
• ENST00000343231
• ENSP00000344477

Symbol

• APT1
• LPL1
• APT1
• LPL1
• APT-1
• LPL-I
• hAPT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
virus perturbation	0.9
gene perturbation	0.81
interacting protein	0.77
metabolite	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.99   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.99   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (7)

Explore Active Ligands

1 – 7 of 7

Palmostatin B

LYPLA1Tchem Enzyme

pKi : 7.47

Palmostatin M

LYPLA1Tchem Enzyme

pIC50 : 8.6

CHEMBL1903566

LYPLA1Tchem Enzyme

pIC50 : 7.77

CHEMBL3133032

LYPLA1Tchem Enzyme

pKi : 6.14

CHEMBL3133034

LYPLA1Tchem Enzyme

pIC50 : 7.57

CHEMBL3133035

LYPLA1Tchem Enzyme

pIC50 : 6.83

CHEMBL600764

LYPLA1Tchem Enzyme

pKi : 6.52

Protein-Protein Interactions (125)

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1 – 10 of 125

• See Interactions on String-DB

TRIM11

Tbio

Family:  Enzyme

Novelty:  0.02243955

p_int:  0.999856072

p_ni:  0.000143928

Data Source:  BioPlex

CTSO

Tbio

Family:  Enzyme

Novelty:  0.09963965

p_int:  0.999749531

p_ni:  0.000184712

p_wrong:  0.000065758

Score:  0.517

Data Source:  BioPlex,STRINGDB

TEAD4

Tchem

Family:  TF

Novelty:  0.0114979

p_int:  0.994353418

p_ni:  0.005630099

p_wrong:  0.000016482

Score:  0.228

Data Source:  BioPlex,STRINGDB

USP47

Tchem

Family:  Enzyme

Novelty:  0.07579226

p_int:  0.988325753

p_ni:  0.011531866

p_wrong:  0.000142381

Data Source:  BioPlex

GTF2E2

Tbio

Novelty:  0.18033153

p_int:  0.986984862

p_ni:  0.012948987

p_wrong:  0.000066152

Data Source:  BioPlex

MTRF1

Tbio

Family:  Enzyme

Novelty:  0.11037387

p_int:  0.89644456

p_ni:  0.09982255

p_wrong:  0.00373289

Data Source:  BioPlex

FCF1

Tdark

Novelty:  0.04202976

p_int:  0.852644907

p_ni:  0.081237414

p_wrong:  0.066117679

Data Source:  BioPlex

NOS3

Tchem

Family:  Enzyme

Novelty:  0.00012407

Score:  0.923

Data Source:  Reactome,STRINGDB

GPCPD1

Tdark

Family:  Enzyme

Novelty:  0.03548168

Score:  0.918

Data Source:  STRINGDB

LCAT

Tchem

Family:  Enzyme

Novelty:  0.00307544

Score:  0.914

Data Source:  STRINGDB

Nearest Tclin Targets (2)

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Upstream (1)

Downstream (1)

1 – 1 of 1

ACHE

Tclin

Family:  Enzyme

KEGG Distance:  2

Common Pathways:  1

1: Glycerophospholipid metabolism

Pathways (5)

Reactome (3)

KEGG (2)

Metabolism (R-HSA-1430728)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nitric oxide: eNOS activation and regulation	15 targets	R-HSA-202131
Reactome	eNOS activation	11 targets	R-HSA-203615

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nitric oxide: eNOS activation and regulation	15 targets	R-HSA-202131
eNOS activation	11 targets	R-HSA-203615

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (4)

Components (3)

Processes (4)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
lipase activity	Inferred from Direct Assay (IDA)	CACAO
palmitoyl-(protein) hydrolase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
carboxylic ester hydrolase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lysophospholipase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Fatty acid metabolism
Hydrolase
Lipid metabolism
Polymorphism
Reference proteome

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	lysophospholipase I		693700
Mouse	lysophospholipase 1	MGI:1344588	18777
Rat	lysophospholipase I	RGD:3025	25514
Dog	lysophospholipase I	VGNC:42890	609018
Horse	lysophospholipase I [Source:HGNC Symbol;Acc:HGNC:6737]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	lysophospholipase I
Mouse	lysophospholipase 1
Rat	lysophospholipase I
Dog	lysophospholipase I
Horse	lysophospholipase I [Source:HGNC Symbol;Acc:HGNC:6737]

Publication Statistics

PubMed Score 88.99

PubMed score by year

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PubTator Score 75.66

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (10)

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10

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PMID	Year	Title