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Tbio
LYPD6
Ly6/PLAUR domain-containing protein 6

Protein Summary
Description
Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334166
  • ENSP00000334463
  • ENSG00000187123
  • ENST00000392854
  • ENSP00000376594
  • ENST00000409381
  • ENSP00000386413
  • ENST00000418762
  • ENSP00000396855
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
tissue sample
0.75
microRNA
0.71
cell type or tissue
0.56
histone modification site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
TMEM68
Tdark
Novelty:  0.61508475
p_int:  0.999998058
p_ni:  0.000001942
Score:  0.234
Data Source:  BioPlex,STRINGDB
TMEM245
Tdark
Novelty:  0.30094854
p_int:  0.999967061
p_ni:  0.000032908
p_wrong:  3.1e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
SLC12A4
Tbio
Family:  Transporter
Novelty:  0.01077688
p_int:  0.99964465
p_ni:  0.00035535
Data Source:  BioPlex
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.998879981
p_ni:  0.001120019
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.998823021
p_ni:  0.001176979
Score:  0.228
Data Source:  BioPlex,STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
p_int:  0.998571188
p_ni:  0.001428812
Score:  0.189
Data Source:  BioPlex,STRINGDB
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.992380562
p_ni:  0.006374711
p_wrong:  0.001244727
Data Source:  BioPlex
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.980140723
p_ni:  0.019471529
p_wrong:  0.000387748
Score:  0.213
Data Source:  BioPlex,STRINGDB
DNM2
Tchem
Novelty:  0.00265965
p_int:  0.979638695
p_ni:  0.020361305
Score:  0.644
Data Source:  BioPlex,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.975163287
p_ni:  0.024836713
Score:  0.41
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 6
VGNC:1992
459652
Mouse
MGI:2443848
320343
Rat
RGD:1587119
679564
Dog
LY6/PLAUR domain containing 6
VGNC:42888
608509
Horse
LY6/PLAUR domain containing 6
VGNC:19855
100056595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 6
Mouse
Rat
Dog
LY6/PLAUR domain containing 6
Horse
LY6/PLAUR domain containing 6
Publication Statistics
PubMed Score 9.96
PubMed score by year
PubTator Score 2.53
PubTator score by year
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Related Publications
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PMID
Year
Title