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Tbio
LYPD3
Ly6/PLAUR domain-containing protein 3

Protein Summary
Description
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244333
  • ENSP00000244333
  • ENSG00000124466

Symbol
  • C4.4A
  • C4.4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.62
tissue sample
0.62
small molecule perturbation
0.55
cellular component
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.37   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.37   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
GALNT10
Tchem
Family:  Enzyme
Novelty:  0.065869
p_int:  0.999999595
p_ni:  1.1e-8
p_wrong:  3.95e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC41A1
Tbio
Family:  Transporter
Novelty:  0.01442757
p_int:  0.999998569
p_ni:  3.49e-7
p_wrong:  0.000001082
Score:  0.188
Data Source:  BioPlex,STRINGDB
PHTF2
Tdark
Novelty:  0.52825058
p_int:  0.999998174
p_ni:  0.000001315
p_wrong:  5.1e-7
Score:  0.327
Data Source:  BioPlex,STRINGDB
DPY19L1
Tdark
Family:  Enzyme
Novelty:  0.34765717
p_int:  0.999994157
p_ni:  0.000005843
Data Source:  BioPlex
TMEM245
Tdark
Novelty:  0.30094854
p_int:  0.999977794
p_ni:  0.000022089
p_wrong:  1.17e-7
Data Source:  BioPlex
TMEM94
Tdark
Novelty:  0.39746809
p_int:  0.999975638
p_ni:  0.000024361
p_wrong:  2e-9
Data Source:  BioPlex
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.99995127
p_ni:  0.000048529
p_wrong:  2.01e-7
Data Source:  BioPlex
REEP1
Tbio
Novelty:  0.02280713
p_int:  0.99988346
p_ni:  0.00004487
p_wrong:  0.000071671
Data Source:  BioPlex
SCAMP1
Tbio
Novelty:  0.03293648
p_int:  0.999757298
p_ni:  0.000242702
Data Source:  BioPlex
BOD1
Tbio
Novelty:  0.06404805
p_int:  0.999699413
p_ni:  0.000196189
p_wrong:  0.000104398
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
56.2
low density lipoprotein cholesterol measurement
1
1
1
36.5
cotinine glucuronidation measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
56.2
low density lipoprotein cholesterol measurement
1
36.5
cotinine glucuronidation measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 3
VGNC:7560
456092
Mouse
MGI:1919684
72434
Rat
RGD:69053
60378
Dog
LY6/PLAUR domain containing 3
VGNC:42885
484471
Horse
LY6/PLAUR domain containing 3
VGNC:19853
100070126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 3
Mouse
Rat
Dog
LY6/PLAUR domain containing 3
Horse
LY6/PLAUR domain containing 3
Publication Statistics
PubMed Score 38.37
PubMed score by year
PubTator Score 25.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title