Tbio LYPD3 Ly6/PLAUR domain-containing protein 3

Protein Summary

Description

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.

Uniprot Accession IDs

• O95274
• Q9UJ74

Gene Name

• LYPD3

Ensembl ID

• ENST00000244333
• ENSP00000244333
• ENSG00000124466

Symbol

• C4.4A
• C4.4A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
disease perturbation	0.62
tissue sample	0.62
small molecule perturbation	0.55
cellular component	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.37   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.37   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (167)

Explore Interacting Targets

1 – 10 of 167

• See Interactions on String-DB

GALNT10

Tchem

Family:  Enzyme

Novelty:  0.065869

p_int:  0.999999595

p_ni:  1.1e-8

p_wrong:  3.95e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

SLC41A1

Tbio

Family:  Transporter

Novelty:  0.01442757

p_int:  0.999998569

p_ni:  3.49e-7

p_wrong:  0.000001082

Score:  0.188

Data Source:  BioPlex,STRINGDB

PHTF2

Tdark

Novelty:  0.52825058

p_int:  0.999998174

p_ni:  0.000001315

p_wrong:  5.1e-7

Score:  0.327

Data Source:  BioPlex,STRINGDB

DPY19L1

Tdark

Family:  Enzyme

Novelty:  0.34765717

p_int:  0.999994157

p_ni:  0.000005843

Data Source:  BioPlex

TMEM245

Tdark

Novelty:  0.30094854

p_int:  0.999977794

p_ni:  0.000022089

p_wrong:  1.17e-7

Data Source:  BioPlex

TMEM94

Tdark

Novelty:  0.39746809

p_int:  0.999975638

p_ni:  0.000024361

p_wrong:  2e-9

Data Source:  BioPlex

CLDND1

Tbio

Novelty:  0.06681793

p_int:  0.99995127

p_ni:  0.000048529

p_wrong:  2.01e-7

Data Source:  BioPlex

REEP1

Tbio

Novelty:  0.02280713

p_int:  0.99988346

p_ni:  0.00004487

p_wrong:  0.000071671

Data Source:  BioPlex

SCAMP1

Tbio

Novelty:  0.03293648

p_int:  0.999757298

p_ni:  0.000242702

Data Source:  BioPlex

BOD1

Tbio

Novelty:  0.06404805

p_int:  0.999699413

p_ni:  0.000196189

p_wrong:  0.000104398

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (5)

Processes (1)

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GO Term	Evidence	Assigned by
laminin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	1	1	1		56.2
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		36.5
cotinine glucuronidation measurement	EFO_0006508	1	1	1		0.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	1		56.2
low density lipoprotein cholesterol measurement	EFO_0004611	1		36.5
cotinine glucuronidation measurement	EFO_0006508	1		0.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
GPI-anchor
Lipoprotein
Membrane
Reference proteome
Repeat
Signal

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
cotinine glucuronidation measurement
low density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	LY6/PLAUR domain containing 3	VGNC:7560	456092
Mouse	Ly6/Plaur domain containing 3	MGI:1919684	72434
Rat	Ly6/Plaur domain containing 3	RGD:69053	60378
Dog	LY6/PLAUR domain containing 3	VGNC:42885	484471
Horse	LY6/PLAUR domain containing 3	VGNC:19853	100070126

Species	Name	OMA	EggNOG	Inparanoid
Chimp	LY6/PLAUR domain containing 3
Mouse	Ly6/Plaur domain containing 3
Rat	Ly6/Plaur domain containing 3
Dog	LY6/PLAUR domain containing 3
Horse	LY6/PLAUR domain containing 3

Publication Statistics

PubMed Score 38.37

PubMed score by year

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PubTator Score 25.28

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (16)

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10

0 of 0

PMID	Year	Title