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Tdark
LYPD2
Ly6/PLAUR domain-containing protein 2

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
CARS2
Tbio
Family:  Enzyme
Novelty:  0.0105933
p_int:  0.999999897
p_ni:  1.03e-7
Data Source:  BioPlex
TMEM132A
Tdark
Novelty:  0.26489093
p_int:  0.999839766
p_ni:  0.000160233
p_wrong:  1e-9
Data Source:  BioPlex
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
p_int:  0.99875774
p_ni:  0.00124226
Data Source:  BioPlex
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
p_int:  0.997671777
p_ni:  0.000827735
p_wrong:  0.001500488
Data Source:  BioPlex
ADAM9
Tchem
Family:  Enzyme
Novelty:  0.00616626
p_int:  0.939686411
p_ni:  0.060312292
p_wrong:  0.000001297
Data Source:  BioPlex
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.905620178
p_ni:  0.094374255
p_wrong:  0.000005567
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.865865534
p_ni:  0.134134466
Data Source:  BioPlex
PLXNA3
Tbio
Novelty:  0.02016528
p_int:  0.780266408
p_ni:  0.219733592
Data Source:  BioPlex
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
p_int:  0.778139837
p_ni:  0.221860163
Data Source:  BioPlex
LY6K
Tbio
Novelty:  0.01861325
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.3
92.4
1
1
0
1.4
80.9
pepsinogen I/II ratio
1
1
1
78.1
2
2
2
70.4
3
2
0
1.1
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
92.4
0
1.4
80.9
pepsinogen I/II ratio
1
78.1
2
70.4
0
1.1
60.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 2
VGNC:14570
738684
Mouse
MGI:1915561
68311
Rat
RGD:1307892
300017
Dog
LY6/PLAUR domain containing 2
VGNC:42884
609016
Horse
LY6/PLAUR domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25215]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LY6/PLAUR domain containing 2
Mouse
Rat
Dog
LY6/PLAUR domain containing 2
Horse
LY6/PLAUR domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25215]
Publication Statistics
PubMed Score 1.13
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title