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Tbio
LYNX1
Ly-6/neurotoxin-like protein 1

Protein Summary
Description
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614491
  • ENSP00000477648
  • ENSG00000180155
  • ENST00000620006
  • ENSP00000478402
  • ENST00000621401
  • ENSP00000478390
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.62
cell line
0.59
transcription factor
0.48
tissue
0.47
transcription factor perturbation
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.81   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.81   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.812
Data Source:  STRINGDB
SLURP1
Tbio
Novelty:  0.00710864
Score:  0.807
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.708
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.686
Data Source:  STRINGDB
LYPD2
Tdark
Novelty:  0.55307434
Score:  0.669
Data Source:  STRINGDB
GML
Tdark
Novelty:  0.04982168
Score:  0.55
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.543
Data Source:  STRINGDB
LYPD6
Tbio
Novelty:  0.13867181
Score:  0.537
Data Source:  STRINGDB
CHRNA1
Tclin
Family:  IC
Novelty:  0.01393364
Score:  0.529
Data Source:  STRINGDB
LYPD1
Tbio
Novelty:  0.10740408
Score:  0.507
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.3
92.4
1
1
0
1.4
80.9
pepsinogen I/II ratio
1
1
1
78.1
2
2
2
70.4
testosterone measurement
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
92.4
0
1.4
80.9
pepsinogen I/II ratio
1
78.1
2
70.4
testosterone measurement
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 31.81
PubMed score by year
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Related Publications
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PMID
Year
Title