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Tchem
LY96
Lymphocyte antigen 96

Protein Summary
Description
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284818
  • ENSP00000284818
  • ENSG00000154589
  • ENST00000518893
  • ENSP00000430533

Symbol
  • ESOP1
  • MD2
  • MD2
  • MD-2
  • ly-96
  • ESOP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease
0.62
PubMedID
0.59
tissue sample
0.59
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753.83   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753.83   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (116)
TLR4
Tchem
Novelty:  0.00010863
Score:  0.999
Data Source:  Reactome,STRINGDB
LY86
Tbio
Novelty:  0.00314575
Score:  0.994
Data Source:  STRINGDB
TLR2
Tchem
Novelty:  0.00023242
Score:  0.989
Data Source:  STRINGDB
TLR1
Tbio
Novelty:  0.00171909
Score:  0.982
Data Source:  STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.976
Data Source:  Reactome,STRINGDB
CD180
Tbio
Novelty:  0.01839955
Score:  0.972
Data Source:  STRINGDB
TIRAP
Tbio
Novelty:  0.00600495
Score:  0.967
Data Source:  Reactome,STRINGDB
LBP
Tbio
Novelty:  0.00185354
Score:  0.966
Data Source:  STRINGDB
HMGB1
Tchem
Family:  TF
Novelty:  0.00043845
Score:  0.963
Data Source:  Reactome,STRINGDB
S100A9
Tchem
Novelty:  0.00185141
Score:  0.963
Data Source:  Reactome,STRINGDB
Pathways (49)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Apoptosis
Reactome
Caspase activation via Death Receptors in the presence of ligand
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Adaptive Immune System
Antigen processing-Cross presentation
Apoptosis
Caspase activation via Death Receptors in the presence of ligand
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
47.7
alkaline phosphatase measurement
1
1
1
45.7
total cholesterol measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
47.7
alkaline phosphatase measurement
1
45.7
total cholesterol measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 96
VGNC:852
746178
Macaque
lymphocyte antigen 96
696778
Mouse
MGI:1341909
17087
Dog
lymphocyte antigen 96
VGNC:42878
610524
Horse
lymphocyte antigen 96
VGNC:19848
100034040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 96
Macaque
lymphocyte antigen 96
Mouse
Dog
lymphocyte antigen 96
Horse
lymphocyte antigen 96
Publication Statistics
PubMed Score 753.83
PubMed score by year
PubTator Score 243.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title