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Tbio
LY9
T-lymphocyte surface antigen Ly-9

Protein Summary
Description
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263285
  • ENSP00000263285
  • ENSG00000122224
  • ENST00000368037
  • ENSP00000357016

Symbol
  • hly9
  • mLY9
  • CD229
  • SLAMF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
tissue sample
0.73
co-expressed gene
0.72
protein domain
0.58
microRNA
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 583   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 583   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
SH2D1A
Tbio
Novelty:  0.0060687
Score:  0.881
Data Source:  STRINGDB
SH2D1B
Tbio
Novelty:  0.01535146
Score:  0.812
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.801
Data Source:  STRINGDB
CD48
Tbio
Novelty:  0.00301661
Score:  0.767
Data Source:  STRINGDB
SLAMF8
Tbio
Novelty:  0.1485993
Score:  0.691
Data Source:  STRINGDB
CD58
Tbio
Novelty:  0.0021531
Score:  0.687
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.678
Data Source:  STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.674
Data Source:  STRINGDB
CTSS
Tchem
Family:  Enzyme
Novelty:  0.00786042
Score:  0.666
Data Source:  STRINGDB
CD2
Tclin
Novelty:  0.00037283
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
92.5
lymphocyte percentage of leukocytes
2
3
3
85.8
2
2
0
1.1
68.5
neutrophil percentage of leukocytes
1
1
1
40.7
1
1
0
1.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
92.5
lymphocyte percentage of leukocytes
3
85.8
0
1.1
68.5
neutrophil percentage of leukocytes
1
40.7
0
1.1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96885
17085
Rat
RGD:1308341
289227
Dog
lymphocyte antigen 9
VGNC:42877
100855726
Horse
lymphocyte antigen 9
VGNC:19847
100058830
Cow
lymphocyte antigen 9
VGNC:31094
528926
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
lymphocyte antigen 9
Horse
lymphocyte antigen 9
Cow
lymphocyte antigen 9
Publication Statistics
PubMed Score 62.57
PubMed score by year
PubTator Score 26.86
PubTator score by year
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Related Publications
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PMID
Year
Title