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Tbio
LY86
Lymphocyte antigen 86

Protein Summary
Description
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230568
  • ENSP00000230568
  • ENSG00000112799
  • ENST00000379953
  • ENSP00000369286

Symbol
  • MD1
  • MD1
  • MD-1
  • MMD-1
  • dJ80N2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
tissue sample
0.7
transcription factor perturbation
0.68
kinase perturbation
0.66
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.57   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.57   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (190)
NBR1
Tbio
Novelty:  0.00893066
p_int:  0.999976102
p_ni:  0.000023898
Data Source:  BioPlex
VEGFB
Tclin
Novelty:  0.00293322
p_int:  0.999636023
p_ni:  0.000041017
p_wrong:  0.00032296
Data Source:  BioPlex
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999083264
p_ni:  0.000620223
p_wrong:  0.000296513
Data Source:  BioPlex
CD55
Tbio
Novelty:  0.0005689
p_int:  0.998055158
p_ni:  0.001831187
p_wrong:  0.000113654
Data Source:  BioPlex
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.99760595
p_ni:  0.000222411
p_wrong:  0.002171638
Data Source:  BioPlex
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.99556122
p_ni:  0.004436875
p_wrong:  0.000001905
Data Source:  BioPlex
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.995506745
p_ni:  0.004492265
p_wrong:  9.9e-7
Data Source:  BioPlex
SAMD1
Tdark
Novelty:  0.21956379
p_int:  0.99515147
p_ni:  0.004848464
p_wrong:  6.7e-8
Data Source:  BioPlex
PXYLP1
Tbio
Family:  Enzyme
Novelty:  0.04672634
p_int:  0.994850179
p_ni:  0.005148025
p_wrong:  0.000001796
Data Source:  BioPlex
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.99463449
p_ni:  0.00536551
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Toll Like Receptor 4 (TLR4) Cascade
Reactome
Toll-like Receptor Cascades
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Toll Like Receptor 4 (TLR4) Cascade
Toll-like Receptor Cascades
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
11
29
98.4
BMI-adjusted hip circumference
5
14
20
95.7
waist-hip ratio
5
4
7
94.2
reticulocyte measurement
3
2
3
65.3
reticulocyte count
5
2
5
64.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
29
98.4
BMI-adjusted hip circumference
20
95.7
waist-hip ratio
7
94.2
reticulocyte measurement
3
65.3
reticulocyte count
5
64.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 86
VGNC:12653
745667
Mouse
MGI:1321404
17084
Rat
RGD:1309936
291359
Dog
lymphocyte antigen 86
VGNC:42876
478712
Horse
lymphocyte antigen 86
VGNC:19846
100630498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 86
Mouse
Rat
Dog
lymphocyte antigen 86
Horse
lymphocyte antigen 86
Publication Statistics
PubMed Score 462.57
PubMed score by year
PubTator Score 6.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title