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Tdark
LY6G5C
Lymphocyte antigen 6 complex locus protein G5c

Protein Summary
Description
May have a role in hematopoietic cell differentiation. LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324540
  • ENSP00000313380
  • ENSG00000111971
  • ENST00000383237
  • ENSP00000372724
  • ENSG00000204428
  • ENST00000383425
  • ENSP00000372917
  • ENSG00000206404
  • ENST00000418117
  • ENSP00000391301
  • ENSG00000228883
  • ENST00000431114
  • ENSP00000391878
  • ENSG00000231325
  • ENST00000455753
  • ENSP00000413765
  • ENSG00000226404
  • ENST00000458081
  • ENSP00000414953
  • ENSG00000237495

Symbol
  • C6orf20
  • G5C
  • NG33
  • G5C
  • NG33
  • C6orf20
  • LY6G5CA
  • LY6G5CB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.57
disease
0.54
small molecule perturbation
0.53
cell line
0.48
phenotype
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
LY6G6C
Tbio
Novelty:  0.07576412
Score:  0.707
Data Source:  STRINGDB
LY6G5B
Tdark
Novelty:  0.07346971
Score:  0.68
Data Source:  STRINGDB
C6orf47
Tdark
Novelty:  0.12805293
Score:  0.647
Data Source:  STRINGDB
APOM
Tbio
Novelty:  0.00505937
Score:  0.639
Data Source:  STRINGDB
ECI1
Tbio
Family:  Enzyme
Novelty:  0.01936227
Score:  0.631
Data Source:  STRINGDB
ABHD16A
Tchem
Family:  Enzyme
Novelty:  0.04797219
Score:  0.595
Data Source:  STRINGDB
LY6G6D
Tbio
Novelty:  0.03244924
Score:  0.583
Data Source:  STRINGDB
LY6G6F
Tbio
Novelty:  0.11261229
Score:  0.559
Data Source:  STRINGDB
VWA7
Tdark
Novelty:  0.15513587
Score:  0.556
Data Source:  STRINGDB
MFSD10
Tbio
Novelty:  0.12830664
Score:  0.551
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (658)
Items per page:
1 – 5 of 658
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
Items per page:
1 – 5 of 658
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 6 family member G5C
VGNC:52015
104006786
Mouse
MGI:2148974
114652
Rat
RGD:735180
294245
Dog
lymphocyte antigen 6 family member G5C
VGNC:42874
403793
Horse
lymphocyte antigen 6 family member G5C
VGNC:19845
100629995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 6 family member G5C
Mouse
Rat
Dog
lymphocyte antigen 6 family member G5C
Horse
lymphocyte antigen 6 family member G5C
Publication Statistics
PubMed Score 14.03
PubMed score by year
PubTator Score 1.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title