You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LY6E
Lymphocyte antigen 6E

Protein Summary
Description
Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292494
  • ENSP00000292494
  • ENSG00000160932
  • ENST00000429120
  • ENSP00000414307
  • ENST00000520466
  • ENSP00000428572
  • ENST00000521003
  • ENSP00000428169
  • ENST00000521699
  • ENSP00000427915
  • ENST00000522024
  • ENSP00000428442
  • ENST00000522971
  • ENSP00000428159
  • ENST00000619718
  • ENSP00000482517
  • ENSG00000278032
  • ENST00000631568
  • ENSP00000488891
  • ENST00000632424
  • ENSP00000488421
  • ENST00000632516
  • ENSP00000487664
  • ENST00000632519
  • ENSP00000488443
  • ENST00000632812
  • ENSP00000488556
  • ENST00000633451
  • ENSP00000488559

Symbol
  • 9804
  • RIGE
  • SCA2
  • TSA1
  • RIGE
  • SCA2
  • RIG-E
  • SCA-2
  • TSA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
PubMedID
0.92
transcription factor perturbation
0.91
gene perturbation
0.84
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.26   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.26   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
PSCA
Tbio
Novelty:  0.00323778
Score:  0.974
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.956
Data Source:  STRINGDB
LYPD2
Tdark
Novelty:  0.55307434
Score:  0.952
Data Source:  STRINGDB
LY6D
Tbio
Novelty:  0.07032941
Score:  0.943
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.94
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.937
Data Source:  STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
Score:  0.937
Data Source:  STRINGDB
LYPD6B
Tdark
Novelty:  0.1409054
Score:  0.935
Data Source:  STRINGDB
LYPD5
Tdark
Novelty:  0.97576337
Score:  0.93
Data Source:  STRINGDB
LY6G6C
Tbio
Novelty:  0.07576412
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
59.3
systolic blood pressure
2
2
2
57
androstenedione measurement
1
1
1
18.3
Diuretic use measurement
2
1
2
11
Calcium channel blocker use measurement
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
59.3
systolic blood pressure
2
57
androstenedione measurement
1
18.3
Diuretic use measurement
2
11
Calcium channel blocker use measurement
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 6 family member E
VGNC:14763
739033
Mouse
MGI:106651
17069
Rat
RGD:1565342
362934
Dog
lymphocyte antigen 6 family member E
VGNC:42873
100683006
Horse
lymphocyte antigen 6 family member E
VGNC:19844
100066193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphocyte antigen 6 family member E
Mouse
Rat
Dog
lymphocyte antigen 6 family member E
Horse
lymphocyte antigen 6 family member E
Publication Statistics
PubMed Score 167.26
PubMed score by year
PubTator Score 46.07
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title