Protein Summary
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.
- ENST00000357872
- ENSP00000350541
- ENSG00000172901
- ENST00000503329
- ENSP00000427418
- ENST00000504467
- ENSP00000423604
- ENST00000512314
- ENSP00000427500
- ENST00000514509
- ENSP00000427574
- AQPEP
- APQ
- AQPEP
- TAQPEP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 0.75 | ||
cell line | 0.7 | ||
gene perturbation | 0.68 | ||
histone modification site profile | 0.67 | ||
microRNA | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.65 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 21 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.65 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 21 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0