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Tbio
LUC7L
Putative RNA-binding protein Luc7-like 1

Protein Summary
Description
May bind to RNA via its Arg/Ser-rich domain. The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293872
  • ENSP00000293872
  • ENSG00000007392
  • ENST00000337351
  • ENSP00000337507
  • ENST00000397783
  • ENSP00000380885

Symbol
  • LUC7L1
  • Luc7
  • SR+89
  • LUC7B1
  • hLuc7B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.95
transcription factor binding site profile
0.85
kinase perturbation
0.84
interacting protein
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.36   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.36   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999991
p_ni:  9e-9
Score:  0.318
Data Source:  BioPlex,STRINGDB
GPATCH8
Tdark
Novelty:  0.45717416
p_int:  0.999999632
p_ni:  3.68e-7
Score:  0.22
Data Source:  BioPlex,STRINGDB
PRPF38B
Tdark
Novelty:  1.02626586
p_int:  0.999989474
p_ni:  0.000003116
p_wrong:  0.00000741
Score:  0.769
Data Source:  BioPlex,STRINGDB
NFKBIL1
Tbio
Novelty:  0.03932489
p_int:  0.999972301
p_ni:  0.000027698
p_wrong:  1e-9
Score:  0.542
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.999759511
p_ni:  0.000240489
Score:  0.413
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999731394
p_ni:  0.000268606
Score:  0.557
Data Source:  BioPlex,STRINGDB
NKTR
Tbio
Novelty:  0.01287691
p_int:  0.999679324
p_ni:  0.000320676
Score:  0.293
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.999377402
p_ni:  0.000622598
Data Source:  BioPlex
SRSF8
Tbio
Novelty:  0.16509556
p_int:  0.999170947
p_ni:  0.000393721
p_wrong:  0.000435333
Score:  0.457
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999001895
p_ni:  0.000998105
Score:  0.549
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
14
22
30
99.9
mean corpuscular hemoglobin
4
7
7
98.8
mean corpuscular volume
6
12
15
98.8
erythrocyte count
7
14
20
98.5
reticulocyte measurement
3
13
18
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
30
99.9
mean corpuscular hemoglobin
7
98.8
mean corpuscular volume
15
98.8
erythrocyte count
20
98.5
reticulocyte measurement
18
98.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LUC7 like
VGNC:9086
467851
Macaque
LUC7 like
694332
Mouse
MGI:1914228
66978
Dog
LUC7 like
VGNC:42863
479898
Horse
LUC7 like
VGNC:19837
100065090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LUC7 like
Macaque
LUC7 like
Mouse
Dog
LUC7 like
Horse
LUC7 like
Publication Statistics
PubMed Score 16.36
PubMed score by year
PubTator Score 49.24
PubTator score by year
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Related Publications
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PMID
Year
Title