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Tbio
LTN1
E3 ubiquitin-protein ligase listerin

Protein Summary
Description
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361371
  • ENSP00000354977
  • ENSG00000198862
  • ENST00000389194
  • ENSP00000373846
  • ENST00000614971
  • ENSP00000478783

Symbol
  • C21orf10
  • C21orf98
  • KIAA0714
  • RNF160
  • ZNF294
  • RNF160
  • ZNF294
  • C21orf10
  • C21orf98
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
microRNA
0.81
transcription factor binding site profile
0.8
interacting protein
0.68
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (356)
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.997428774
p_ni:  0.002571226
Data Source:  BioPlex
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.970857982
p_ni:  0.029142018
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.963559773
p_ni:  0.036440227
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.943238999
p_ni:  0.056761001
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.94036918
p_ni:  0.05963082
Data Source:  BioPlex
VASN
Tbio
Novelty:  0.05424159
p_int:  0.928700813
p_ni:  0.071299187
Data Source:  BioPlex
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.928612461
p_ni:  0.071387539
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.916720252
p_ni:  0.083279748
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.905799458
p_ni:  0.094200542
Data Source:  BioPlex
P01889
Tbio
Novelty:  0.00790207
p_int:  0.899887397
p_ni:  0.100112603
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
78.1
reticulocyte measurement
3
1
3
71.2
reticulocyte count
2
1
2
70.6
electrocardiography
1
1
3
31.7
body weight
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
78.1
reticulocyte measurement
3
71.2
reticulocyte count
2
70.6
electrocardiography
3
31.7
body weight
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
listerin E3 ubiquitin protein ligase 1
VGNC:1143
458494
Macaque
listerin E3 ubiquitin protein ligase 1
714068
Mouse
MGI:1926163
78913
Rat
RGD:1311238
288308
Dog
listerin E3 ubiquitin protein ligase 1
VGNC:42862
100685637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
listerin E3 ubiquitin protein ligase 1
Macaque
listerin E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
listerin E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 57.28
PubMed score by year
PubTator Score 8.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title