LTN1
E3 ubiquitin-protein ligase listerin
Protein Summary
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
- ENST00000361371
- ENSP00000354977
- ENSG00000198862
- ENST00000389194
- ENSP00000373846
- ENST00000614971
- ENSP00000478783
- C21orf10
- C21orf98
- KIAA0714
- RNF160
- ZNF294
- RNF160
- ZNF294
- C21orf10
- C21orf98
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
microRNA | 0.81 | ||
transcription factor binding site profile | 0.8 | ||
interacting protein | 0.68 | ||
gene perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.28 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.28 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0