Protein Summary
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting a ...more
- ENST00000231751
- ENSP00000231751
- ENSG00000012223
- ENST00000426532
- ENSP00000405719
- GIG12
- LF
- LF
- HLF2
- GIG12
- HEL110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
PubMedID | 1 | ||
biological term | 0.97 | ||
molecular function | 0.96 | ||
small molecule perturbation | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 856.76 (req: < 5)
Gene RIFs: 185 (req: <= 3)
Antibodies: 1219 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 856.76 (req: >= 5)
Gene RIFs: 185 (req: > 3)
Antibodies: 1219 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999997774
p_ni: 0.000002226
Data Source: BioPlex
HBM
Novelty: 0.02658671
p_int: 0.999801173
p_ni: 0.000198827
Score: 0.2
Data Source: BioPlex,STRINGDB
CCDC148
Novelty: 2.81805259
p_int: 0.999161952
p_ni: 0.000838047
Score: 0.196
Data Source: BioPlex,STRINGDB
POLL
Family: Enzyme
Novelty: 0.00244645
p_int: 0.994555369
p_ni: 0.005444631
Score: 0.17
Data Source: BioPlex,STRINGDB
FN3KRP
Family: Kinase
Novelty: 0.10259418
p_int: 0.97039602
p_ni: 0.02960398
Score: 0.235
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.968423716
p_ni: 0.031576279
p_wrong: 5e-9
Data Source: BioPlex
TMEM237
Novelty: 0.27005874
p_int: 0.960652736
p_ni: 0.039347264
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (84)
Reactome (11)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Disease | ||||
Reactome | Immune System | ||||
Reactome | Infectious disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amyloid fiber formation | ||||
Antimicrobial peptides | ||||
Disease | ||||
Immune System | ||||
Infectious disease | ||||
Viral Interactions (0)
Gene Ontology Terms (58)
Functions (7)
Components (13)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte count | 4 | 4 | 4 | 97.2 | |||||
macrophage inflammatory protein 1b measurement | 1 | 3 | 3 | 96 | |||||
monocyte percentage of leukocytes | 2 | 4 | 4 | 94.3 | |||||
Oral ulcer | 1 | 2 | 0 | 1.1 | 93.2 | ||||
CCL2 measurement | 2 | 3 | 3 | 90.4 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte count | 4 | 97.2 | |||||
macrophage inflammatory protein 1b measurement | 3 | 96 | |||||
monocyte percentage of leukocytes | 4 | 94.3 | |||||
Oral ulcer | 0 | 1.1 | 93.2 | ||||
CCL2 measurement | 3 | 90.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lactotransferrin | VGNC:1866 | 460325 | |||||
Macaque | lactotransferrin | 713115 | ||||||
Mouse | MGI:96837 | 17002 | ||||||
Rat | RGD:1305445 | 301034 | ||||||
Dog | lactotransferrin | VGNC:42861 | 484787 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lactotransferrin | |||||
Macaque | lactotransferrin | |||||
Mouse | ||||||
Rat | ||||||
Dog | lactotransferrin | |||||
Publication Statistics
PubMed Score 856.76
PubMed score by year
PubTator Score 214.74
PubTator score by year
Related Publications
Text Mined References (285)
GeneRif Annotations (185)
Items per page:
0 of 0
PMID | Year | Title |
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