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Tchem
LTC4S
Leukotriene C4 synthase

Protein Summary
Description
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292596
  • ENSP00000292596
  • ENSG00000213316
  • ENST00000639087
  • ENSP00000492334
  • ENSG00000283887
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.79
PubMedID
0.7
molecular function
0.67
cellular component
0.64
disease
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.58   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.58   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 137
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (137)
CHEMBL4251024
Rendered image for CHEMBL4251024
CHEMBL2387503
Rendered image for CHEMBL2387503
example 36 [WO2016177845]
Rendered image for example 36 [WO2016177845]
TK05
Rendered image for TK05
CHEMBL3903201
Rendered image for CHEMBL3903201
CHEMBL4549822
Rendered image for CHEMBL4549822
CHEMBL3961833
Rendered image for CHEMBL3961833
CHEMBL4567083
Rendered image for CHEMBL4567083
CHEMBL4464773
Rendered image for CHEMBL4464773
CHEMBL3914270
Rendered image for CHEMBL3914270
Protein-Protein Interactions (37)
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.988
Data Source:  Reactome,STRINGDB
LTA4H
Tchem
Family:  Enzyme
Novelty:  0.00505614
Score:  0.98
Data Source:  STRINGDB
ALOX5AP
Tchem
Family:  Enzyme
Novelty:  0.00165143
Score:  0.947
Data Source:  Reactome,STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.921
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.904
Data Source:  STRINGDB
MGST1
Tbio
Family:  Enzyme
Novelty:  0.00681882
Score:  0.846
Data Source:  STRINGDB
CYSLTR1
Tclin
Family:  GPCR
Novelty:  0.00337777
Score:  0.81
Data Source:  STRINGDB
CYSLTR2
Tchem
Family:  GPCR
Novelty:  0.00895224
Score:  0.802
Data Source:  STRINGDB
MGST3
Tbio
Family:  Enzyme
Novelty:  0.02891864
Score:  0.761
Data Source:  STRINGDB
FFAR3
Tchem
Family:  GPCR
Novelty:  0.00746169
Score:  0.73
Data Source:  STRINGDB
Pathways (30)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DHA-derived sulfido conjugates
Reactome
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Reactome
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DHA-derived sulfido conjugates
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
5
78.3
neutrophil count
4
4
5
78.3
monocyte count
2
2
2
75.6
monocyte count
2
2
2
75.6
monocyte percentage of leukocytes
2
2
2
72.7
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
78.3
neutrophil count
5
78.3
monocyte count
2
75.6
monocyte count
2
75.6
monocyte percentage of leukocytes
2
72.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukotriene C4 synthase
VGNC:13542
739986
Mouse
MGI:107498
17001
Rat
RGD:620677
114097
Dog
leukotriene C4 synthase
VGNC:51742
607316
Horse
leukotriene C4 synthase [Source:HGNC Symbol;Acc:HGNC:6719]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukotriene C4 synthase
Mouse
Rat
Dog
leukotriene C4 synthase
Horse
leukotriene C4 synthase [Source:HGNC Symbol;Acc:HGNC:6719]
Publication Statistics
PubMed Score 117.58
PubMed score by year
PubTator Score 197.39
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title