Protein Summary
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
- ENST00000292596
- ENSP00000292596
- ENSG00000213316
- ENST00000639087
- ENSP00000492334
- ENSG00000283887
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.79 | ||
PubMedID | 0.7 | ||
molecular function | 0.67 | ||
cellular component | 0.64 | ||
disease | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.58 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.58 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 137
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0