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Tbio
LTBP3
Latent-transforming growth factor beta-binding protein 3

Protein Summary
Description
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301873
  • ENSP00000301873
  • ENSG00000168056
  • ENST00000322147
  • ENSP00000326647

Symbol
  • DASS
  • LTBP2
  • LTBP-3
  • STHAG6
  • pp6425
  • GPHYSD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.8
cell type or tissue
0.73
transcription factor
0.66
small molecule perturbation
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.28   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.28   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
DNAJC10
Tbio
Novelty:  0.02258366
p_int:  0.774190875
p_ni:  0.225809117
p_wrong:  8e-9
Score:  0.26
Data Source:  BioPlex,STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.965
Data Source:  Reactome,STRINGDB
TGFB3
Tbio
Novelty:  0.00068568
Score:  0.962
Data Source:  Reactome,STRINGDB
TGFB2
Tbio
Novelty:  0.00050804
Score:  0.957
Data Source:  Reactome,STRINGDB
FRMD8
Tdark
Novelty:  0.39375892
Score:  0.723
Data Source:  STRINGDB
FSTL3
Tbio
Novelty:  0.01238701
Score:  0.651
Data Source:  STRINGDB
CDH17
Tbio
Novelty:  0.00035679
Score:  0.638
Data Source:  STRINGDB
WNT10A
Tbio
Novelty:  0.00641352
Score:  0.62
Data Source:  STRINGDB
EHBP1L1
Tdark
Novelty:  0.39557718
Score:  0.573
Data Source:  STRINGDB
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
97.8
heel bone mineral density
3
5
7
95.1
mean platelet volume
3
2
3
93.2
BMI-adjusted waist-hip ratio
5
4
6
90.2
cup-to-disc ratio measurement
4
2
5
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
97.8
heel bone mineral density
7
95.1
mean platelet volume
3
93.2
BMI-adjusted waist-hip ratio
6
90.2
cup-to-disc ratio measurement
5
88.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
latent transforming growth factor beta binding protein 3
VGNC:1094
451325
Mouse
MGI:1101355
16998
Rat
RGD:62057
83838
Dog
latent transforming growth factor beta binding protein 3
VGNC:42858
483736
Horse
latent transforming growth factor beta binding protein 3
VGNC:19833
100146561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
latent transforming growth factor beta binding protein 3
Mouse
Rat
Dog
latent transforming growth factor beta binding protein 3
Horse
latent transforming growth factor beta binding protein 3
Publication Statistics
PubMed Score 55.28
PubMed score by year
PubTator Score 22.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title