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Tbio
LTBP1
Latent-transforming growth factor beta-binding protein 1

Protein Summary
Description
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several differen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404525
  • ENSP00000385359
  • ENSG00000049323
  • ENST00000404816
  • ENSP00000386043
  • ENST00000407925
  • ENSP00000384091
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.92
transcription factor
0.88
transcription factor perturbation
0.88
molecular function
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.62   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.62   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.999995274
p_ni:  0.000004726
Score:  0.172
Data Source:  BioPlex,STRINGDB
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999992098
p_ni:  0.000007902
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999979974
p_ni:  0.000020026
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999880837
p_ni:  0.000119163
Data Source:  BioPlex
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999610199
p_ni:  0.000383744
p_wrong:  0.000006058
Data Source:  BioPlex
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.999522549
p_ni:  0.00047745
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.999492223
p_ni:  0.000507777
Data Source:  BioPlex
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.99925543
p_ni:  0.000744565
p_wrong:  6e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
CSN1S1
Tbio
Family:  Enzyme
Novelty:  0.00200522
p_int:  0.998120733
p_ni:  0.001879218
p_wrong:  4.9e-8
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.996382277
p_ni:  0.003617017
p_wrong:  7.06e-7
Score:  0.304
Data Source:  BioPlex,STRINGDB
Pathways (10)
Elastic fibre formation (R-HSA-1566948)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Metabolism of proteins
Reactome
Molecules associated with elastic fibres
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Metabolism of proteins
Molecules associated with elastic fibres
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
5
94.2
intraocular pressure measurement
3
3
3
85.2
BMI-adjusted hip circumference
3
8
11
80.9
3
3
0
1.1
70.9
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
94.2
intraocular pressure measurement
3
85.2
BMI-adjusted hip circumference
11
80.9
0
1.1
70.9
1
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
latent transforming growth factor beta binding protein 1
VGNC:321
459143
Macaque
latent transforming growth factor beta binding protein 1
709607
Mouse
MGI:109151
268977
Rat
RGD:68379
59107
Dog
latent transforming growth factor beta binding protein 1
VGNC:42856
475720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
latent transforming growth factor beta binding protein 1
Macaque
latent transforming growth factor beta binding protein 1
Mouse
Rat
Dog
latent transforming growth factor beta binding protein 1
Publication Statistics
PubMed Score 112.62
PubMed score by year
PubTator Score 83.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title