LTB4R
Leukotriene B4 receptor 1
Protein Summary
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
- ENST00000345363
- ENSP00000307445
- ENSG00000213903
- ENST00000396782
- ENSP00000380002
- ENST00000396789
- ENSP00000380008
- ENST00000646659
- ENSP00000495785
- ENSG00000285456
- ENST00000646739
- ENSP00000494730
- ENST00000647085
- ENSP00000495466
- BLT
- BLT1
- BLTR
- CMKRL1
- GPR16
- P2RY7
- BLT1
- BLTR
- P2Y7
- GPR16
- LTBR1
- P2RY7
- CMKRL1
- LTB4R1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.71 | ||
PubMedID | 0.7 | ||
gene perturbation | 0.64 | ||
transcription factor perturbation | 0.61 | ||
ligand (chemical) | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.81 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 506 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.81 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 506 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 201
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1